KHSRP

An Error has occured retrieving Wikidata item for infobox KHSRP‏ (KH-type splicing regulatory protein) هوَ بروتين يُشَفر بواسطة جين KHSRP في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Min H، Turck CW، Nikolic JM، Black DL (مايو 1997). "A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer". Genes Dev. ج. 11 ع. 8: 1023–36. DOI:10.1101/gad.11.8.1023. PMID:9136930.
^ "Entrez Gene: KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)". مؤرشف من الأصل في 2010-12-05.
^ Davis-Smyth T، Duncan RC، Zheng T، Michelotti G، Levens D (يناير 1997). "The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators". J Biol Chem. ج. 271 ع. 49: 31679–87. DOI:10.1074/jbc.271.49.31679. PMID:8940189.

قراءة متعمقة

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Chou MY، Rooke N، Turck CW، Black DL (1999). "hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells". Mol. Cell. Biol. ج. 19 ع. 1: 69–77. PMC:83866. PMID:9858532.
Ring HZ، Vameghi-Meyers V، Nikolic JM، وآخرون (1999). "Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17". Genomics. ج. 56 ع. 3: 350–2. DOI:10.1006/geno.1998.5725. PMID:10087204.
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Chou MY، Underwood JG، Nikolic J، وآخرون (2000). "Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing". Mol. Cell. ج. 5 ع. 6: 949–57. DOI:10.1016/S1097-2765(00)80260-9. PMID:10911989.
Markovtsov V، Nikolic JM، Goldman JA، وآخرون (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. ج. 20 ع. 20: 7463–79. DOI:10.1128/MCB.20.20.7463-7479.2000. PMC:86300. PMID:11003644.
Chen CY، Gherzi R، Ong SE، وآخرون (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. ج. 107 ع. 4: 451–64. DOI:10.1016/S0092-8674(01)00578-5. PMID:11719186.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Hall MP، Huang S، Black DL (2004). "Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA". Mol. Biol. Cell. ج. 15 ع. 2: 774–86. DOI:10.1091/mbc.E03-09-0692. PMC:329392. PMID:14657238.
Gherzi R، Lee KY، Briata P، وآخرون (2004). "A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery". Mol. Cell. ج. 14 ع. 5: 571–83. DOI:10.1016/j.molcel.2004.05.002. PMID:15175153.
Suswam EA، Nabors LB، Huang Y، وآخرون (2005). "IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR". Int. J. Cancer. ج. 113 ع. 6: 911–9. DOI:10.1002/ijc.20675. PMID:15514971.
Wickham L، Benjannet S، Marcinkiewicz E، وآخرون (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". J. Neurochem. ج. 92 ع. 1: 93–102. DOI:10.1111/j.1471-4159.2004.02840.x. PMID:15606899.
Chou CF، Mulky A، Maitra S، وآخرون (2006). "Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay". Mol. Cell. Biol. ج. 26 ع. 10: 3695–706. DOI:10.1128/MCB.26.10.3695-3706.2006. PMC:1489004. PMID:16648466.
Beausoleil SA، Villén J، Gerber SA، وآخرون (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. ج. 24 ع. 10: 1285–92. DOI:10.1038/nbt1240. PMID:16964243.
Olsen JV، Blagoev B، Gnad F، وآخرون (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. ج. 127 ع. 3: 635–48. DOI:10.1016/j.cell.2006.09.026. PMID:17081983.
Gherzi R، Trabucchi M، Ponassi M، وآخرون (2007). "The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling". PLoS Biol. ج. 5 ع. 1: e5. DOI:10.1371/journal.pbio.0050005. PMC:1702562. PMID:17177604.
Ewing RM، Chu P، Elisma F، وآخرون (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. ج. 3 ع. 1: 89. DOI:10.1038/msb4100134. PMC:1847948. PMID:17353931.

هذه بذرة مقالة عن بروتين بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid9136930-1] Min H، Turck CW، Nikolic JM، Black DL (مايو 1997). "A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer". Genes Dev. ج. 11 ع. 8: 1023–36. DOI:10.1101/gad.11.8.1023. PMID:9136930.

[entrez-2] "Entrez Gene: KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)". مؤرشف من الأصل في 2010-12-05.

[pmid8940189-3] Davis-Smyth T، Duncan RC، Zheng T، Michelotti G، Levens D (يناير 1997). "The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators". J Biol Chem. ج. 271 ع. 49: 31679–87. DOI:10.1074/jbc.271.49.31679. PMID:8940189.

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