CBFB

An Error has occured retrieving Wikidata item for infobox CBFB‏ (Core-binding factor subunit beta) هوَ بروتين يُشَفر بواسطة جين CBFB في الإنسان.^[1]^[2]^[3]^[4]^[5]

الوظيفة

الأهمية السريرية

المراجع

^ The Cancer Genome Atlas Network (2012). "Comprehensive molecular portraits of human breast tumours". Nature. Nature Publishing Group. ج. 490 ع. 7418: 61–70. DOI:10.1038/nature11412. PMC:3465532. PMID:23000897. مؤرشف من الأصل في 2012-09-27. اطلع عليه بتاريخ 2012-09-24.
^ Liu P، Tarle SA، Hajra A، Claxton DF، Marlton P، Freedman M، Siciliano MJ، Collins FS (سبتمبر 1993). "Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia". Science. ج. 261 ع. 5124: 1041–4. DOI:10.1126/science.8351518. PMID:8351518.
^ "CBFB Gene." Genetics Home Reference. US National Library of Medicine, 10 Sept. 2015. Web. 27 Sept. 2015.
^ "Entrez Gene: CBFB core-binding factor, beta subunit". مؤرشف من الأصل في 2010-12-05.
^ Liu P، Seidel N، Bodine D، Speck N، Tarle S، Collins FS (نوفمبر 1995). "Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail". Cold Spring Harb Symp Quant Biol. ج. 59: 547–53. DOI:10.1101/sqb.1994.059.01.061. PMID:7587111.

قراءة متعمقة

Hart SM، Foroni L (2003). "Core binding factor genes and human leukemia". Haematologica. ج. 87 ع. 12: 1307–23. PMID:12495904.
Bae SC، Takahashi E، Zhang YW، وآخرون (1995). "Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain". Gene. ج. 159 ع. 2: 245–8. DOI:10.1016/0378-1119(95)00060-J. PMID:7622058.
Bonaldo MF، Lennon G، Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. ج. 6 ع. 9: 791–806. DOI:10.1101/gr.6.9.791. PMID:8889548.
Hillier LD، Lennon G، Becker M، وآخرون (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. ج. 6 ع. 9: 807–28. DOI:10.1101/gr.6.9.807. PMID:8889549.
Hajra A، Collins FS (1997). "Structure of the leukemia-associated human CBFB gene". Genomics. ج. 38 ع. 1: 107. DOI:10.1006/geno.1996.0603. PMID:9064279.
Chiba N، Watanabe T، Nomura S، وآخرون (1997). "Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development". Oncogene. ج. 14 ع. 21: 2543–52. DOI:10.1038/sj.onc.1201109. PMID:9191054.
Tanaka Y، Watanabe T، Chiba N، وآخرون (1997). "The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures". Oncogene. ج. 15 ع. 6: 677–83. DOI:10.1038/sj.onc.1201235. PMID:9264408.
Kitabayashi I، Ida K، Morohoshi F، وآخرون (1998). "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1". Mol. Cell. Biol. ج. 18 ع. 2: 846–58. PMC:108796. PMID:9447981.
Levanon D، Goldstein RE، Bernstein Y، وآخرون (1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proc. Natl. Acad. Sci. U.S.A. ج. 95 ع. 20: 11590–5. DOI:10.1073/pnas.95.20.11590. PMC:21685. PMID:9751710.
Kogan SC، Lagasse E، Atwater S، وآخرون (1998). "The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia". Proc. Natl. Acad. Sci. U.S.A. ج. 95 ع. 20: 11863–8. DOI:10.1073/pnas.95.20.11863. PMC:21731. PMID:9751756.
Goger M، Gupta V، Kim WY، وآخرون (1999). "Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta". Nat. Struct. Biol. ج. 6 ع. 7: 620–3. DOI:10.1038/10664. PMID:10404215.
Lutterbach B، Hou Y، Durst KL، Hiebert SW (1999). "The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor". Proc. Natl. Acad. Sci. U.S.A. ج. 96 ع. 22: 12822–7. DOI:10.1073/pnas.96.22.12822. PMC:23113. PMID:10536006.
Warren AJ، Bravo J، Williams RL، Rabbitts TH (2000). "Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta". مجلة EMBO العلمية. ج. 19 ع. 12: 3004–15. DOI:10.1093/emboj/19.12.3004. PMC:203359. PMID:10856244.
Kanto S، Chiba N، Tanaka Y، وآخرون (2000). "The PEBP2beta/CBF beta-SMMHC chimeric protein is localized both in the cell membrane and nuclear subfractions of leukemic cells carrying chromosomal inversion 16". Leukemia. ج. 14 ع. 7: 1253–9. DOI:10.1038/sj.leu.2401821. PMID:10914550.
O'Reilly J، Chipper L، Springall F، Herrmann R (2000). "A unique structural abnormality of chromosome 16 resulting in a CBF beta-MYH11 fusion transcript in a patient with acute myeloid leukemia, FAB M4". Cancer Genet. Cytogenet. ج. 121 ع. 1: 52–5. DOI:10.1016/S0165-4608(00)00235-1. PMID:10958941.
Bravo J، Li Z، Speck NA، Warren AJ (2001). "The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp". Nat. Struct. Biol. ج. 8 ع. 4: 371–8. DOI:10.1038/86264. PMID:11276260.
Bäckström S، Wolf-Watz M، Grundström C، وآخرون (2002). "The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding". J. Mol. Biol. ج. 322 ع. 2: 259–72. DOI:10.1016/S0022-2836(02)00702-7. PMID:12217689.

هذه بذرة مقالة عن بروتين بحاجة للتوسيع. فضلًا شارك في تحريرها.

[nature11412-1] The Cancer Genome Atlas Network (2012). "Comprehensive molecular portraits of human breast tumours". Nature. Nature Publishing Group. ج. 490 ع. 7418: 61–70. DOI:10.1038/nature11412. PMC:3465532. PMID:23000897. مؤرشف من الأصل في 2012-09-27. اطلع عليه بتاريخ 2012-09-24.

[pmid8351518-2] Liu P، Tarle SA، Hajra A، Claxton DF، Marlton P، Freedman M، Siciliano MJ، Collins FS (سبتمبر 1993). "Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia". Science. ج. 261 ع. 5124: 1041–4. DOI:10.1126/science.8351518. PMID:8351518.

[3] "CBFB Gene." Genetics Home Reference. US National Library of Medicine, 10 Sept. 2015. Web. 27 Sept. 2015.

[entrez-4] "Entrez Gene: CBFB core-binding factor, beta subunit". مؤرشف من الأصل في 2010-12-05.

[pmid7587111-5] Liu P، Seidel N، Bodine D، Speck N، Tarle S، Collins FS (نوفمبر 1995). "Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail". Cold Spring Harb Symp Quant Biol. ج. 59: 547–53. DOI:10.1101/sqb.1994.059.01.061. PMID:7587111.

[1]

[2]

[3]

[4]

[5]