WIF1
من أرابيكا، الموسوعة العربية الحرة
المزيد من اللغات
المزيد من الإجراءات
An Error has occured retrieving Wikidata item for infobox WIF1 (Wnt inhibitory factor 1) هوَ بروتين يُشَفر بواسطة جين WIF1 في الإنسان.[1][2][3][4]
الوظيفة
![[أيقونة]](/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
- ^ "Entrez Gene: WIF1 WNT inhibitory factor 1". مؤرشف من الأصل في 2010-12-05.
- ^ Hsieh JC، Kodjabachian L، Rebbert ML، Rattner A، Smallwood PM، Samos CH، Nusse R، Dawid IB، Nathans J (أبريل 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. ج. 398 ع. 6726: 431–6. DOI:10.1038/18899. PMID:10201374.
- ^ Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. ج. 43 ع. 3: 227–30. DOI:10.1007/s11745-007-3144-3. PMID:18256869.
- ^ Malinauskas T، Aricescu AR، Lu W، Siebold C، Jones EY (يوليو 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. ج. 18 ع. 8: 886–893. DOI:10.1038/nsmb.2081. PMC:3430870. PMID:21743455.
قراءة متعمقة
- Shepelev MV، Korobko EV، Korobko IV (2006). "[WIF1: perspectives of application in oncology]". Mol. Gen. Mikrobiol. Virusol. ع. 4: 3–7. PMID:17094650.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Clark HF، Gurney AL، Abaya E، وآخرون (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. ج. 13 ع. 10: 2265–70. DOI:10.1101/gr.1293003. PMC:403697. PMID:12975309.
- Reguart N، He B، Xu Z، وآخرون (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1". Biochem. Biophys. Res. Commun. ج. 323 ع. 1: 229–34. DOI:10.1016/j.bbrc.2004.08.075. PMID:15351726.
- Esufali S، Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation". Oncogene. ج. 23 ع. 50: 8260–71. DOI:10.1038/sj.onc.1208007. PMID:15377999.
- Ohigashi T، Mizuno R، Nakashima J، وآخرون (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells". Prostate. ج. 62 ع. 1: 61–8. DOI:10.1002/pros.20117. PMID:15389810.
- Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
- Simon M، Grandage VL، Linch DC، Khwaja A (2005). "Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia". Oncogene. ج. 24 ع. 14: 2410–20. DOI:10.1038/sj.onc.1208431. PMID:15735743.
- Taniguchi H، Yamamoto H، Hirata T، وآخرون (2005). "Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers". Oncogene. ج. 24 ع. 53: 7946–52. DOI:10.1038/sj.onc.1208910. PMID:16007117.
- Lin YC، You L، Xu Z، وآخرون (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines". Biochem. Biophys. Res. Commun. ج. 341 ع. 2: 635–40. DOI:10.1016/j.bbrc.2005.12.220. PMID:16427602.
- Urakami S، Shiina H، Enokida H، وآخرون (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway". Clin. Cancer Res. ج. 12 ع. 2: 383–91. DOI:10.1158/1078-0432.CCR-05-1344. PMID:16428476.
- Liepinsh E، Bányai L، Patthy L، Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1". J. Mol. Biol. ج. 357 ع. 3: 942–50. DOI:10.1016/j.jmb.2006.01.047. PMID:16476441.
- Batra S، Shi Y، Kuchenbecker KM، وآخرون (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma". Biochem. Biophys. Res. Commun. ج. 342 ع. 4: 1228–32. DOI:10.1016/j.bbrc.2006.02.084. PMID:16516163.
- Chim CS، Chan WW، Pang A، Kwong YL (2006). "Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor". Leukemia. ج. 20 ع. 5: 907–9. DOI:10.1038/sj.leu.2404176. PMID:16525492.
- Urakami S، Shiina H، Enokida H، وآخرون (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. ج. 12 ع. 7 Pt 1: 2109–16. DOI:10.1158/1078-0432.CCR-05-2468. PMID:16609023.
- Milutinovic S، D'Alessio AC، Detich N، Szyf M (2007). "Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes". Carcinogenesis. ج. 28 ع. 3: 560–71. DOI:10.1093/carcin/bgl167. PMID:17012225.
- Queimado L، Lopes CS، Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors". Genes Chromosomes Cancer. ج. 46 ع. 3: 215–25. DOI:10.1002/gcc.20402. PMID:17171686.
- Chan SL، Cui Y، van Hasselt A، وآخرون (2007). "The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas". Lab. Invest. ج. 87 ع. 7: 644–50. DOI:10.1038/labinvest.3700547. PMID:17384664.
- Veeck J، Wild PJ، Fuchs T، وآخرون (2009). "Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer". BMC Cancer. ج. 9: 1–13. DOI:10.1186/1471-2407-9-217. PMC:2717119. PMID:19570204.
