REG1A

An Error has occured retrieving Wikidata item for infobox REG1A‏ (Regenerating family member 1 alpha) هوَ بروتين يُشَفر بواسطة جين REG1A في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Gharib B، Fox MF، Bartoli C، Giorgi D، Sansonetti A، Swallow DM، Dagorn JC، Berge-lefranc JL (أغسطس 1993). "Human تجدد protein/lithostathine genes map to chromosome 2p12". Ann Hum Genet. ج. 57 ع. Pt 1: 9–16. DOI:10.1111/j.1469-1809.1993.tb00882.x. PMID:8333731.
^ "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)". مؤرشف من الأصل في 2010-12-05.
^ Watanabe T، Yonekura H، Terazono K، Yamamoto H، Okamoto H (يونيو 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. ج. 265 ع. 13: 7432–9. PMID:2332435.

قراءة متعمقة

De Reggi M، Gharib B (2002). "Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions". Curr. Protein Pept. Sci. ج. 2 ع. 1: 19–42. DOI:10.2174/1389203013381233. PMID:12369899.
Itoh T، Tsuzuki H، Katoh T، Teraoka H، Matsumoto K، Yoshida N، Terazono K، Watanabe T، Yonekura H، Yamamoto H (1990). "Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae". FEBS Lett. ج. 272 ع. 1–2: 85–8. DOI:10.1016/0014-5793(90)80454-Q. PMID:2226837.
de la Monte SM، Ozturk M، Wands JR (1990). "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain". J. Clin. Invest. ج. 86 ع. 3: 1004–13. DOI:10.1172/JCI114762. PMC:296822. PMID:2394826.
De Caro AM، Adrich Z، Fournet B، Capon C، Bonicel JJ، De Caro JD، Rovery M (1989). "N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue". Biochim. Biophys. Acta. ج. 994 ع. 3: 281–4. DOI:10.1016/0167-4838(89)90305-1. PMID:2493268.
Giorgi D، Bernard JP، Rouquier S، Iovanna J، Sarles H، Dagorn JC (1989). "Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis". J. Clin. Invest. ج. 84 ع. 1: 100–6. DOI:10.1172/JCI114128. PMC:303958. PMID:2525567.
Stewart TA (1989). "The human reg gene encodes pancreatic stone protein". Biochem. J. ج. 260 ع. 2: 622–3. PMC:1138718. PMID:2764894.
Terazono K، Yamamoto H، Takasawa S، Shiga K، Yonemura Y، Tochino Y، Okamoto H (1988). "A novel gene activated in regenerating islets". J. Biol. Chem. ج. 263 ع. 5: 2111–4. PMID:2963000.
Rouimi P، Bonicel J، Rovery M، De Caro A (1987). "Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein". FEBS Lett. ج. 216 ع. 2: 195–9. DOI:10.1016/0014-5793(87)80688-9. PMID:3108036.
Rouimi P، de Caro J، Bonicel J، Rovery M، de Caro A (1988). "The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice". FEBS Lett. ج. 229 ع. 1: 171–4. DOI:10.1016/0014-5793(88)80820-2. PMID:3345835.
Montalto G، Bonicel J، Multigner L، Rovery M، Sarles H، De Caro A (1987). "Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein". Biochem. J. ج. 238 ع. 1: 227–32. PMC:1147119. PMID:3541906.
De Caro AM، Bonicel JJ، Rouimi P، De Caro JD، Sarles H، Rovery M (1987). "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice". Eur. J. Biochem. ج. 168 ع. 1: 201–7. DOI:10.1111/j.1432-1033.1987.tb13405.x. PMID:3665916.
Gross J، Carlson RI، Brauer AW، Margolies MN، Warshaw AL، Wands JR (1986). "Isolation, characterization, and distribution of an unusual pancreatic human secretory protein". J. Clin. Invest. ج. 76 ع. 6: 2115–26. DOI:10.1172/JCI112216. PMC:424321. PMID:3908481.
Perfetti R، Hawkins AL، Griffin CA، Egan JM، Zenilman ME، Shuldiner AR (1994). "Assignment of the human pancreatic regenerating (REG) gene to chromosome 2p12". Genomics. ج. 20 ع. 2: 305–7. DOI:10.1006/geno.1994.1173. PMID:8020983.
Otonkoski T، Mally MI، Hayek A (1994). "Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells". Diabetes. ج. 43 ع. 9: 1164–6. DOI:10.2337/diabetes.43.9.1164. PMID:8070617.
Moriizumi S، Watanabe T، Unno M، Nakagawara K، Suzuki Y، Miyashita H، Yonekura H، Okamoto H (1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta". Biochim. Biophys. Acta. ج. 1217 ع. 2: 199–202. DOI:10.1016/0167-4781(94)90035-3. PMID:8110835.
Bartoli C، Gharib B، Giorgi D، Sansonetti A، Dagorn JC، Bergé-Lefranc JL (1993). "A gene homologous to the reg gene is expressed in the human pancreas". FEBS Lett. ج. 327 ع. 3: 289–93. DOI:10.1016/0014-5793(93)81006-L. PMID:8348956.
Bertrand JA، Pignol D، Bernard JP، Verdier JM، Dagorn JC، Fontecilla-Camps JC (1996). "Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation". EMBO J. ج. 15 ع. 11: 2678–84. PMC:450203. PMID:8654365.
Patard L، Stoven V، Gharib B، Bontems F، Lallemand JY، De Reggi M (1997). "What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy". Protein Eng. ج. 9 ع. 11: 949–57. DOI:10.1093/protein/9.11.949. PMID:8961348.

هذه بذرة مقالة عن جين على كروموسوم 2 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid8333731-1] Gharib B، Fox MF، Bartoli C، Giorgi D، Sansonetti A، Swallow DM، Dagorn JC، Berge-lefranc JL (أغسطس 1993). "Human تجدد protein/lithostathine genes map to chromosome 2p12". Ann Hum Genet. ج. 57 ع. Pt 1: 9–16. DOI:10.1111/j.1469-1809.1993.tb00882.x. PMID:8333731.

[entrez-2] "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)". مؤرشف من الأصل في 2010-12-05.

[pmid2332435-3] Watanabe T، Yonekura H، Terazono K، Yamamoto H، Okamoto H (يونيو 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem. ج. 265 ع. 13: 7432–9. PMID:2332435.

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