PAG1

An Error has occured retrieving Wikidata item for infobox PAG1‏ (Phosphoprotein membrane anchor with glycosphingolipid microdomains 1) هوَ بروتين يُشَفر بواسطة جين PAG1 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1". مؤرشف من الأصل في 2010-12-05.
^ Brdicka T، Pavlistova D، Leo A، Bruyns E، Korinek V، Angelisova P، Scherer J، Shevchenko A، Hilgert I، Cerny J، Drbal K، Kuramitsu Y، Kornacker B، Horejsi V، Schraven B (مايو 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med. ج. 191 ع. 9: 1591–604. DOI:10.1084/jem.191.9.1591. PMC:2213442. PMID:10790433.

قراءة متعمقة

Wen ST، Van Etten RA (1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. ج. 11 ع. 19: 2456–67. DOI:10.1101/gad.11.19.2456. PMC:316562. PMID:9334312.
Brdicková N، Brdicka T، Andera L، وآخرون (2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. ج. 507 ع. 2: 133–6. DOI:10.1016/S0014-5793(01)02955-6. PMID:11684085.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Tedoldi S، Paterson JC، Hansmann ML، وآخرون (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. ج. 107 ع. 1: 213–21. DOI:10.1182/blood-2005-06-2273. PMID:16160011.
Jiang LQ، Feng X، Zhou W، وآخرون (2006). "Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation". Oncogene. ج. 25 ع. 40: 5495–506. DOI:10.1038/sj.onc.1209554. PMID:16636672.
Takeuchi S (2007). "Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis". Protein J. ج. 25 ع. 4: 295–9. DOI:10.1007/s10930-006-9015-6. PMID:16947079.
Roberts AE، Araki T، Swanson KD، وآخرون (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. ج. 39 ع. 1: 70–4. DOI:10.1038/ng1926. PMID:17143285.
Smida M، Posevitz-Fejfar A، Horejsi V، وآخرون (2007). "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation". Blood. ج. 110 ع. 2: 596–615. DOI:10.1182/blood-2006-07-038752. PMID:17389760.

هذه بذرة مقالة عن جين على كروموسوم 8 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1". مؤرشف من الأصل في 2010-12-05.

[pmid10790433-2] Brdicka T، Pavlistova D، Leo A، Bruyns E، Korinek V، Angelisova P، Scherer J، Shevchenko A، Hilgert I، Cerny J، Drbal K، Kuramitsu Y، Kornacker B، Horejsi V، Schraven B (مايو 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med. ج. 191 ع. 9: 1591–604. DOI:10.1084/jem.191.9.1591. PMC:2213442. PMID:10790433.

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