MST1R

An Error has occured retrieving Wikidata item for infobox MST1R‏ (Macrophage stimulating 1 receptor) هوَ بروتين يُشَفر بواسطة جين MST1R في الإنسان.^[1]^[2]^[1]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ ^أ ^ب Ronsin C، Muscatelli F، Mattei MG، Breathnach R (مايو 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. ج. 8 ع. 5: 1195–202. PMID:8386824.
^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)". مؤرشف من الأصل في 2010-12-05.
^ Gaudino G، Follenzi A، Naldini L، Collesi C، Santoro M، Gallo KA، Godowski PJ، Comoglio PM (أغسطس 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. ج. 13 ع. 15: 3524–32. PMC:395256. PMID:8062829.

قراءة متعمقة

Li BQ، Wang MH، Kung HF، وآخرون (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. ج. 216 ع. 1: 110–8. DOI:10.1006/bbrc.1995.2598. PMID:7488076.
Wang MH، Ronsin C، Gesnel MC، وآخرون (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science. ج. 266 ع. 5182: 117–9. DOI:10.1126/science.7939629. PMID:7939629.
Gaudino G، Follenzi A، Naldini L، وآخرون (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. ج. 13 ع. 15: 3524–32. PMC:395256. PMID:8062829.
Lee ST، Strunk KM، Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. ج. 8 ع. 12: 3403–10. PMID:8247543.
Collesi C، Santoro MM، Gaudino G، Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype". Mol. Cell. Biol. ج. 16 ع. 10: 5518–26. PMC:231551. PMID:8816464.
Bonaldo MF، Lennon G، Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. ج. 6 ع. 9: 791–806. DOI:10.1101/gr.6.9.791. PMID:8889548.
Iwama A، Yamaguchi N، Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. ج. 15 ع. 21: 5866–75. PMC:452340. PMID:8918464.
Sakamoto O، Iwama A، Amitani R، وآخرون (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. ج. 99 ع. 4: 701–9. DOI:10.1172/JCI119214. PMC:507853. PMID:9045873.
Follenzi A، Bakovic S، Gual P، وآخرون (2000). "Cross-talk between the proto-oncogenes Met and Ron". Oncogene. ج. 19 ع. 27: 3041–9. DOI:10.1038/sj.onc.1203620. PMID:10871856.
Chen YQ، Zhou YQ، Fisher JH، Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo". Oncogene. ج. 21 ع. 41: 6382–6. DOI:10.1038/sj.onc.1205783. PMID:12214279.
Chen YQ، Zhou YQ، Fu LH، وآخرون (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais". Carcinogenesis. ج. 23 ع. 11: 1811–9. DOI:10.1093/carcin/23.11.1811. PMID:12419829.
Zhou YQ، He C، Chen YQ، وآخرون (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential". Oncogene. ج. 22 ع. 2: 186–97. DOI:10.1038/sj.onc.1206075. PMID:12527888.
Danilkovitch-Miagkova A، Duh FM، Kuzmin I، وآخرون (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus". Proc. Natl. Acad. Sci. U.S.A. ج. 100 ع. 8: 4580–5. DOI:10.1073/pnas.0837136100. PMC:153598. PMID:12676986.
Rampino T، Gregorini M، Soccio G، وآخرون (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol. ج. 27 ع. 6: 779–85. DOI:10.1097/00000478-200306000-00008. PMID:12766581.
Penengo L، Rubin C، Yarden Y، Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor". Oncogene. ج. 22 ع. 24: 3669–79. DOI:10.1038/sj.onc.1206585. PMID:12802274.
Maggiora P، Lorenzato A، Fracchioli S، وآخرون (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res. ج. 288 ع. 2: 382–9. DOI:10.1016/S0014-4827(03)00250-7. PMID:12915129.
Santoro MM، Gaudino G، Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell. ج. 5 ع. 2: 257–71. DOI:10.1016/S1534-5807(03)00201-6. PMID:12919677.
Angeloni D، Danilkovitch-Miagkova A، Miagkov A، وآخرون (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. ج. 279 ع. 5: 3726–32. DOI:10.1074/jbc.M309342200. PMID:14597639.
van den Akker E، van Dijk T، Parren-van Amelsvoort M، وآخرون (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors". Blood. ج. 103 ع. 12: 4457–65. DOI:10.1182/blood-2003-08-2713. PMID:14982882.
Raeppel S، Gaudette G، وآخرون (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett. ج. 20 ع. 9: 2745–9. DOI:10.1016/j.bmcl.2010.03.073.

هذه بذرة مقالة عن جين على كروموسوم 3 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid8386824-1] أ ^ب Ronsin C، Muscatelli F، Mattei MG، Breathnach R (مايو 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. ج. 8 ع. 5: 1195–202. PMID:8386824.

[entrez-2] "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)". مؤرشف من الأصل في 2010-12-05.

[pmid8062829-3] Gaudino G، Follenzi A، Naldini L، Collesi C، Santoro M، Gallo KA، Godowski PJ، Comoglio PM (أغسطس 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. ج. 13 ع. 15: 3524–32. PMC:395256. PMID:8062829.

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