RGS8

An Error has occured retrieving Wikidata item for infobox RGS8‏ (Regulator of G protein signaling 8) هوَ بروتين يُشَفر بواسطة جين RGS8 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: RGS8 regulator of G-protein signalling 8". مؤرشف من الأصل في 2010-12-05.
^ Sood R، Bonner TI، Makalowska I، Stephan DA، Robbins CM، Connors TD، Morgenbesser SD، Su K، Faruque MU، Pinkett H، Graham C، Baxevanis AD، Klinger KW، Landes GM، Trent JM، Carpten JD (أبريل 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. ج. 73 ع. 2: 211–22. DOI:10.1006/geno.2001.6500. PMID:11318611.

قراءة متعمقة

Berman DM، Wilkie TM، Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. ج. 86 ع. 3: 445–452. DOI:10.1016/S0092-8674(00)80117-8. PMID:8756726.
Harrington JJ، Sherf B، Rundlett S، وآخرون (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. ج. 19 ع. 5: 440–5. DOI:10.1038/88107. PMID:11329013.
Luo X، Popov S، Bera AK، Wilkie TM، Muallem S (2001). "RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations". Molecular Cell. ج. 7 ع. 3: 651–660. DOI:10.1016/S1097-2765(01)00211-8. PMID:11463389.
Pashkov V، Huang J، Parameswara VK، Kedzierski W، Kurrasch DM، Tall GG، Esser V، Gerard RD، Uyeda K، Towle HC، Wilkie TM (2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner". J Biol Chem. ج. 286 ع. 17: 15116–15125. DOI:10.1074/jbc.M110.216234. PMC:3083217. PMID:21357625.
Popov S، Yu K، Kozasa T، Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro". Proc Natl Acad Sci USA. ج. 94 ع. 14: 7216–20. DOI:10.1073/pnas.94.14.7216. PMC:23796. PMID:9207071.
Popov SG، Krishna UM، Falck JR، Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J Biol Chem. ج. 275 ع. 25: 18962–8. DOI:10.1074/jbc.M001128200. PMID:10747990.
Ross EM، Wilkie TM (2000). "GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins". Annual Review of Biochemistry. ج. 69: 795–827. DOI:10.1146/annurev.biochem.69.1.795. PMID:10966476.
Saitoh O، Murata Y، Odagiri M، وآخرون (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 15: 10138–43. DOI:10.1073/pnas.152085999. PMC:126637. PMID:12110731.
Sierra DA، Gilbert DJ، Householder D، Grishin NV، Yu K، Ukidwe P، Barker SA، He W، Wensel TG، Otero G، Brown G، Copeland NG، Jenkins NA، Wilkie TM (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. ج. 79 ع. 2: 177–85. DOI:10.1006/geno.2002.6693. PMID:11829488.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Masuho I، Itoh M، Itoh H، Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression". J. Neurochem. ج. 88 ع. 1: 161–8. DOI:10.1046/j.1471-4159.2003.02139.x. PMID:14675160.
Larminie C، Murdock P، Walhin JP، وآخرون (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Res. Mol. Brain Res. ج. 122 ع. 1: 24–34. DOI:10.1016/j.molbrainres.2003.11.014. PMID:14992813.
Saitoh O، Yoshihiro K (2005). "Biochemical and electrophysiological analyses of RGS8 function". Meth. Enzymol. ج. 390: 129–48. DOI:10.1016/S0076-6879(04)90009-2. PMID:15488175.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Benians A، Nobles M، Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein". Biochem. Soc. Trans. ج. 32 ع. Pt 6: 1045–7. DOI:10.1042/BST0321045. PMID:15506959.
Benians A، Nobles M، Hosny S، Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics". J. Biol. Chem. ج. 280 ع. 14: 13383–94. DOI:10.1074/jbc.M410163200. PMID:15677457.
Gregory SG، Barlow KF، McLay KE، وآخرون (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. ج. 441 ع. 7091: 315–21. DOI:10.1038/nature04727. PMID:16710414.
Villasenor A، Wang ZV، Rivera LB، Ocal O، Asterholm IW، Scherer PE، Brekken RA، Cleaver O، Wilkie TM (2010). "Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes". Disease Models & Mechanisms. ج. 3 ع. 9–10: 567–580. DOI:10.1242/dmm.003210. PMC:2931535. PMID:20616094.
Wilkie TM، Kinch L (2005). "New roles for Galpha and RGS proteins: communication continues despite pulling sisters apart". Current Biology. ج. 15 ع. 20: R843-54. DOI:10.1016/j.cub.2005.10.008. PMID:16243026.