SPDEF

An Error has occured retrieving Wikidata item for infobox SPDEF‏ (SAM pointed domain containing ETS transcription factor) هوَ بروتين يُشَفر بواسطة جين SPDEF في الإنسان.^[1]^[2]^[3]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Oettgen P؛ Finger E؛ Sun Z؛ Akbarali Y؛ Thamrongsak U؛ Boltax J؛ Grall F؛ Dube A؛ Weiss A؛ Brown L؛ Quinn G؛ Kas K؛ Endress G؛ Kunsch C؛ Libermann TA (فبراير 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem. ج. 275 ع. 2: 1216–25. DOI:10.1074/jbc.275.2.1216. PMID:10625666.
^ Johannessen JV؛ Finseth I (يوليو 1983). "Electron micrographs in five minutes". Ultrastruct Pathol. ج. 4 ع. 1: 97–100. DOI:10.3109/01913128309140576. PMID:6857767.
^ ^أ ^ب "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor". مؤرشف من الأصل في 2010-12-05.

قراءة متعمقة

Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions". Comparative Biochemistry and Physiology A. ج. 53 ع. 3: 285–9. DOI:10.1016/S0300-9629(76)80037-0. PMID:2437.
Yamada N؛ Tamai Y؛ Miyamoto H؛ Nozaki M (2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member". Gene. ج. 241 ع. 2: 267–74. DOI:10.1016/S0378-1119(99)00484-9. PMID:10675039.
Chen H؛ Nandi AK؛ Li X؛ Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. ج. 62 ع. 2: 338–40. PMID:11809674.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Thompson HG، Harris JW، Wold BJ، وآخرون (2003). "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells". Oncogene. ج. 22 ع. 15: 2322–33. DOI:10.1038/sj.onc.1206325. PMID:12700667.
Feldman RJ، Sementchenko VI، Gayed M، وآخرون (2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression". Cancer Res. ج. 63 ع. 15: 4626–31. PMID:12907642.
Mungall AJ، Palmer SA، Sims SK، وآخرون (2003). "The DNA sequence and analysis of human chromosome 6". Nature. ج. 425 ع. 6960: 805–11. DOI:10.1038/nature02055. PMID:14574404.
Ghadersohi A، Odunsi K، Lele S، وآخرون (2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules". Oncol. Rep. ج. 11 ع. 2: 453–8. DOI:10.3892/or.11.2.453. PMID:14719083.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Chen H؛ Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". J. Cell. Biochem. ج. 94 ع. 1: 168–77. DOI:10.1002/jcb.20297. PMID:15523673.
Wang Y، Feng L، Said M، وآخرون (2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site". Biochemistry. ج. 44 ع. 19: 7095–106. DOI:10.1021/bi047352t. PMID:15882048.
Fowler M، Borazanci E، McGhee L، وآخرون (2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". J. Cell. Biochem. ج. 97 ع. 1: 1–17. DOI:10.1002/jcb.20664. PMID:16237704.
Gunawardane RN، Sgroi DC، Wrobel CN، وآخرون (2006). "Novel role for PDEF in epithelial cell migration and invasion". Cancer Res. ج. 65 ع. 24: 11572–80. DOI:10.1158/0008-5472.CAN-05-1196. PMC:2919290. PMID:16357167.
Rodabaugh KJ، Mhawech-Fauceglia P، Groth J، وآخرون (2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors". Int. J. Gynecol. Pathol. ج. 26 ع. 1: 10–5. DOI:10.1097/01.pgp.0000225386.41244.bd. PMID:17197890.
Park KS، Korfhagen TR، Bruno MD، وآخرون (2007). "SPDEF regulates goblet cell hyperplasia in the airway epithelium". J. Clin. Invest. ج. 117 ع. 4: 978–88. DOI:10.1172/JCI29176. PMC:1810569. PMID:17347682.

هذه بذرة مقالة عن جين على كروموسوم 6 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid10625666-1] Oettgen P؛ Finger E؛ Sun Z؛ Akbarali Y؛ Thamrongsak U؛ Boltax J؛ Grall F؛ Dube A؛ Weiss A؛ Brown L؛ Quinn G؛ Kas K؛ Endress G؛ Kunsch C؛ Libermann TA (فبراير 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem. ج. 275 ع. 2: 1216–25. DOI:10.1074/jbc.275.2.1216. PMID:10625666.

[pmid6857767-2] Johannessen JV؛ Finseth I (يوليو 1983). "Electron micrographs in five minutes". Ultrastruct Pathol. ج. 4 ع. 1: 97–100. DOI:10.3109/01913128309140576. PMID:6857767.

[entrez-3] أ ^ب "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor". مؤرشف من الأصل في 2010-12-05.

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