APBA1

An Error has occured retrieving Wikidata item for infobox APBA1‏ (Amyloid beta precursor protein binding family A member 1) هوَ بروتين يُشَفر بواسطة جين APBA1 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Duclos F، Koenig M (مايو 1995). "Comparison of primary structure of a neuron-specific protein, X11, between human and mouse". Mamm Genome. ج. 6 ع. 1: 57–8. DOI:10.1007/BF00350899. PMID:7719031.
^ "Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)". مؤرشف من الأصل في 2010-12-05.
^ Duclos F، Boschert U، Sirugo G، Mandel JL، Hen R، Koenig M (فبراير 1993). "Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system". Proc Natl Acad Sci U S A. ج. 90 ع. 1: 109–13. DOI:10.1073/pnas.90.1.109. PMC:45609. PMID:7678331.

قراءة متعمقة

van der Geer P، Pawson T (1995). "The PTB domain: a new protein module implicated in signal transduction". Trends Biochem. Sci. ج. 20 ع. 7: 277–80. DOI:10.1016/S0968-0004(00)89043-X. PMID:7545337.
Chen WJ، Goldstein JL، Brown MS (1990). "NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor". J. Biol. Chem. ج. 265 ع. 6: 3116–23. PMID:1968060.
Borg JP، Ooi J، Levy E، Margolis B (1996). "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein". Mol. Cell. Biol. ج. 16 ع. 11: 6229–41. DOI:10.1128/mcb.16.11.6229. PMC:231626. PMID:8887653.
Zhang Z، Lee CH، Mandiyan V، Borg JP، Margolis B، Schlessinger J، Kuriyan J (1997). "Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain". EMBO J. ج. 16 ع. 20: 6141–50. DOI:10.1093/emboj/16.20.6141. PMC:1326298. PMID:9321393.
Okamoto M، Südhof TC (1998). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis". J. Biol. Chem. ج. 272 ع. 50: 31459–64. DOI:10.1074/jbc.272.50.31459. PMID:9395480.
Blanco G، Irving NG، Brown SD، Miller CC، McLoughlin DM (1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm. Genome. ج. 9 ع. 6: 473–5. DOI:10.1007/s003359900800. PMID:9585438.
Borg JP، Yang Y، De Taddéo-Borg M، Margolis B، Turner RS (1998). "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion". J. Biol. Chem. ج. 273 ع. 24: 14761–6. DOI:10.1074/jbc.273.24.14761. PMID:9614075.
Butz S، Okamoto M، Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. ج. 94 ع. 6: 773–82. DOI:10.1016/S0092-8674(00)81736-5. PMID:9753324.
Borg JP، Straight SW، Kaech SM، de Taddéo-Borg M، Kroon DE، Karnak D، Turner RS، Kim SK، Margolis B (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. ج. 273 ع. 48: 31633–6. DOI:10.1074/jbc.273.48.31633. PMID:9822620.
Borg JP، Lõpez-Figueroa MO، de Taddèo-Borg M، Kroon DE، Turner RS، Watson SJ، Margolis B (1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain". J. Neurosci. ج. 19 ع. 4: 1307–16. PMID:9952408.
Maximov A، Südhof TC، Bezprozvanny I (1999). "Association of neuronal calcium channels with modular adaptor proteins". J. Biol. Chem. ج. 274 ع. 35: 24453–6. DOI:10.1074/jbc.274.35.24453. PMID:10455105.
Mueller HT، Borg JP، Margolis B، Turner RS (2001). "Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains". J. Biol. Chem. ج. 275 ع. 50: 39302–6. DOI:10.1074/jbc.M008453200. PMID:11010978.
Biederer T، Südhof TC (2001). "Mints as adaptors. Direct binding to neurexins and recruitment of munc18". J. Biol. Chem. ج. 275 ع. 51: 39803–6. DOI:10.1074/jbc.C000656200. PMID:11036064.
Lau KF، McLoughlin DM، Standen C، Miller CC (2001). "X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains". Mol. Cell. Neurosci. ج. 16 ع. 5: 557–65. DOI:10.1006/mcne.2000.0898. PMID:11083918.
McLoughlin DM، Standen CL، Lau KF، Ackerley S، Bartnikas TP، Gitlin JD، Miller CC (2001). "The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity". J. Biol. Chem. ج. 276 ع. 12: 9303–7. DOI:10.1074/jbc.M010023200. PMID:11115513.
Bécamel C، Alonso G، Galéotti N، Demey E، Jouin P، Ullmer C، Dumuis A، Bockaert J، Marin P (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. ج. 21 ع. 10: 2332–42. DOI:10.1093/emboj/21.10.2332. PMC:126011. PMID:12006486.
Ho CS، Marinescu V، Steinhilb ML، Gaut JR، Turner RS، Stuenkel EL (2002). "Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism". J. Biol. Chem. ج. 277 ع. 30: 27021–8. DOI:10.1074/jbc.M201823200. PMID:12016213.

هذه بذرة مقالة عن جين على كروموسوم 9 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid7719031-1] Duclos F، Koenig M (مايو 1995). "Comparison of primary structure of a neuron-specific protein, X11, between human and mouse". Mamm Genome. ج. 6 ع. 1: 57–8. DOI:10.1007/BF00350899. PMID:7719031.

[entrez-2] "Entrez Gene: APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)". مؤرشف من الأصل في 2010-12-05.

[pmid7678331-3] Duclos F، Boschert U، Sirugo G، Mandel JL، Hen R، Koenig M (فبراير 1993). "Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system". Proc Natl Acad Sci U S A. ج. 90 ع. 1: 109–13. DOI:10.1073/pnas.90.1.109. PMC:45609. PMID:7678331.

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