RAB3A

من أرابيكا، الموسوعة الحرة
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An Error has occured retrieving Wikidata item for infobox RAB3A‏ (RAB3A, member RAS oncogene family) هوَ بروتين يُشَفر بواسطة جين RAB3A في الإنسان.[1][2][3]

الوظيفة

الأهمية السريرية

المراجع

  1. ^ Rousseau-Merck MF، Zahraoui A، Bernheim A، Touchot N، Miglierina R، Tavitian A، Berger R (يناير 1990). "Chromosome mapping of the human ras-related rab3A gene to 19p13.2". Genomics. ج. 5 ع. 4: 694–8. DOI:10.1016/0888-7543(89)90110-9. PMID:2687157.
  2. ^ "Entrez Gene: RAB3A RAB3A, member RAS oncogene family". مؤرشف من الأصل في 2010-12-05.
  3. ^ Brondyk WH، McKiernan CJ، Fortner KA، Stabila P، Holz RW، Macara IG (مارس 1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol Cell Biol. ج. 15 ع. 3: 1137–43. PMC:230335. PMID:7532276.

قراءة متعمقة

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  • Zahraoui A، Touchot N، Chardin P، Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". J. Biol. Chem. ج. 264 ع. 21: 12394–401. PMID:2501306.
  • Farnsworth CC، Seabra MC، Ericsson LH، Gelb MH، Glomset JA (1995). "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A". Proc. Natl. Acad. Sci. U.S.A. ج. 91 ع. 25: 11963–7. DOI:10.1073/pnas.91.25.11963. PMC:45356. PMID:7991565.
  • McKiernan CJ، Brondyk WH، Macara IG (1993). "The Rab3A GTPase interacts with multiple factors through the same effector domain. Mutational analysis of cross-linking of Rab3A to a putative target protein". J. Biol. Chem. ج. 268 ع. 32: 24449–52. PMID:8226995.
  • Trask B، Fertitta A، Christensen M، Youngblom J، Bergmann A، Copeland A، de Jong P، Mohrenweiser H، Olsen A، Carrano A (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. ج. 15 ع. 1: 133–45. DOI:10.1006/geno.1993.1021. PMID:8432525.
  • Johannes L، Perez F، Laran-Chich MP، Henry JP، Darchen F (1996). "Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II". Eur. J. Biochem. ج. 239 ع. 2: 362–8. DOI:10.1111/j.1432-1033.1996.0362u.x. PMID:8706741.
  • Burton JL، Slepnev V، De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4". J. Biol. Chem. ج. 272 ع. 6: 3663–8. DOI:10.1074/jbc.272.6.3663. PMID:9013620.
  • Geppert M، Goda Y، Stevens CF، Südhof TC (1997). "The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion". Nature. ج. 387 ع. 6635: 810–4. DOI:10.1038/42954. PMID:9194562.
  • Martincic I، Peralta ME، Ngsee JK (1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". J. Biol. Chem. ج. 272 ع. 43: 26991–8. DOI:10.1074/jbc.272.43.26991. PMID:9341137.
  • Ostermeier C، Brunger AT (1999). "Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A". Cell. ج. 96 ع. 3: 363–74. DOI:10.1016/S0092-8674(00)80549-8. PMID:10025402.
  • Jung YJ، Lee TH، Lee JY، Kim JH، Park JB (1999). "Phosphatidic acid is important to the translocation of Rab3A from the cytosol to phospholipid membranes". NeuroReport. ج. 10 ع. 13: 2859–63. DOI:10.1097/00001756-199909090-00029. PMID:10511453.
  • Sullivan M، Olsen AS، Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND". Cell. Signal. ج. 11 ع. 10: 735–42. DOI:10.1016/S0898-6568(99)00037-6. PMID:10574328.
  • Clabecq A، Henry JP، Darchen F (2000). "Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP". J. Biol. Chem. ج. 275 ع. 41: 31786–91. DOI:10.1074/jbc.M003705200. PMID:10859313.
  • Haynes LP، Evans GJ، Morgan A، Burgoyne RD (2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells". J. Biol. Chem. ج. 276 ع. 13: 9726–32. DOI:10.1074/jbc.M006959200. PMID:11134008.
  • Zhang Y، Luan Z، Liu A، Hu G (2001). "The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins". FEBS Lett. ج. 497 ع. 2–3: 99–102. DOI:10.1016/S0014-5793(01)02450-4. PMID:11377421.
  • Luo HR، Saiardi A، Nagata E، Ye K، Yu H، Jung TS، Luo X، Jain S، Sawa A، Snyder SH (2001). "GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase". Neuron. ج. 31 ع. 3: 439–51. DOI:10.1016/S0896-6273(01)00384-1. PMID:11516400.
  • Piiper A، Leser J، Lutz MP، Beil M، Zeuzem S (2001). "Subcellular distribution and function of Rab3A-D in pancreatic acinar AR42J cells". Biochem. Biophys. Res. Commun. ج. 287 ع. 3: 746–51. DOI:10.1006/bbrc.2001.5651. PMID:11563859.
  • Kuroda TS، Fukuda M، Ariga H، Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. ج. 277 ع. 11: 9212–8. DOI:10.1074/jbc.M112414200. PMID:11773082.