UPF1
من أرابيكا، الموسوعة العربية الحرة
المزيد من اللغات
المزيد من الإجراءات
An Error has occured retrieving Wikidata item for infobox UPF1 (UPF1, RNA helicase and ATPase) هوَ بروتين يُشَفر بواسطة جين UPF1 في الإنسان.[1][2]
الوظيفة
![[أيقونة]](/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
- ^ Applequist SE، Selg M، Raman C، Jack HM (مارس 1997). "Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein". Nucleic Acids Res. ج. 25 ع. 4: 814–21. DOI:10.1093/nar/25.4.814. PMC:146496. PMID:9064659.
- ^ Perlick HA، Medghalchi SM، Spencer FA، Kendzior RJ Jr، Dietz HC (نوفمبر 1996). "Mammalian orthologues of a yeast regulator of nonsense transcript stability". Proc Natl Acad Sci U S A. ج. 93 ع. 20: 10928–32. DOI:10.1073/pnas.93.20.10928. PMC:38260. PMID:8855285.
قراءة متعمقة
- Azzalin CM، Lingner J (2006). "The double life of UPF1 in RNA and DNA stability pathways". Cell Cycle. ج. 5 ع. 14: 1496–8. DOI:10.4161/cc.5.14.3093. PMID:16861888.
- Horikoshi M، Sekimizu K، Natori S (1984). "Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex". J. Biol. Chem. ج. 259 ع. 1: 608–11. PMID:6200476.
- Nagase T، Seki N، Ishikawa K، وآخرون (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. ج. 3 ع. 5: 321–9, 341–54. DOI:10.1093/dnares/3.5.321. PMID:9039502.
- Czaplinski K، Ruiz-Echevarria MJ، Paushkin SV، وآخرون (1998). "The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs". Genes Dev. ج. 12 ع. 11: 1665–77. DOI:10.1101/gad.12.11.1665. PMC:316864. PMID:9620853.
- Page MF، Carr B، Anders KR، وآخرون (1999). "SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in Caenorhabditis elegans and Related to Upf1p of Yeast". Mol. Cell. Biol. ج. 19 ع. 9: 5943–51. PMC:84455. PMID:10454541.
- Bhattacharya A، Czaplinski K، Trifillis P، وآخرون (2000). "Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay". RNA. ج. 6 ع. 9: 1226–35. DOI:10.1017/S1355838200000546. PMC:1369996. PMID:10999600.
- Mendell JT، Medghalchi SM، Lake RG، وآخرون (2000). "Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes". Mol. Cell. Biol. ج. 20 ع. 23: 8944–57. DOI:10.1128/MCB.20.23.8944-8957.2000. PMC:86549. PMID:11073994.
- Serin G، Gersappe A، Black JD، وآخرون (2001). "Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4)". Mol. Cell. Biol. ج. 21 ع. 1: 209–23. DOI:10.1128/MCB.21.1.209-223.2001. PMC:88795. PMID:11113196.
- Lykke-Andersen J، Shu MD، Steitz JA (2001). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. ج. 103 ع. 7: 1121–31. DOI:10.1016/S0092-8674(00)00214-2. PMID:11163187.
- Denning G، Jamieson L، Maquat LE، وآخرون (2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. ج. 276 ع. 25: 22709–14. DOI:10.1074/jbc.C100144200. PMID:11331269.
- Yamashita A، Ohnishi T، Kashima I، وآخرون (2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. ج. 15 ع. 17: 2215–28. DOI:10.1101/gad.913001. PMC:312771. PMID:11544179.
- Lykke-Andersen J، Shu MD، Steitz JA (2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1". Science. ج. 293 ع. 5536: 1836–9. DOI:10.1126/science.1062786. PMID:11546874.
- Carastro LM، Tan CK، Selg M، وآخرون (2002). "Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta". Nucleic Acids Res. ج. 30 ع. 10: 2232–43. DOI:10.1093/nar/30.10.2232. PMC:115286. PMID:12000843.
- Mendell JT، ap Rhys CM، Dietz HC (2002). "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts". Science. ج. 298 ع. 5592: 419–22. DOI:10.1126/science.1074428. PMID:12228722.
- Lykke-Andersen J (2003). "Identification of a Human Decapping Complex Associated with hUpf Proteins in Nonsense-Mediated Decay". Mol. Cell. Biol. ج. 22 ع. 23: 8114–21. DOI:10.1128/MCB.22.23.8114-8121.2002. PMC:134073. PMID:12417715.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Chiu SY، Serin G، Ohara O، Maquat LE (2003). "Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. ج. 9 ع. 1: 77–87. DOI:10.1261/rna.2137903. PMC:1370372. PMID:12554878.
- Schell T، Köcher T، Wilm M، وآخرون (2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". Biochem. J. ج. 373 ع. Pt 3: 775–83. DOI:10.1042/BJ20021920. PMC:1223536. PMID:12723973.
