LRP6

An Error has occured retrieving Wikidata item for infobox LRP6‏ (LDL receptor related protein 6) هوَ بروتين يُشَفر بواسطة جين LRP6 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6". مؤرشف من الأصل في 2010-12-05.
^ Brown SD، Twells RC، Hey PJ، Cox RD، Levy ER، Soderman AR، Metzker ML، Caskey CT، Todd JA، Hess JF (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem. Biophys. Res. Commun. ج. 248 ع. 3: 879–88. DOI:10.1006/bbrc.1998.9061. PMID:9704021.

قراءة متعمقة

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Baens M، Wlodarska I، Corveleyn A، وآخرون (1999). "A physical, transcript, and deletion map of chromosome region 12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p)". Genomics. ج. 56 ع. 1: 40–50. DOI:10.1006/geno.1998.5685. PMID:10036184.
Tamai K، Semenov M، Kato Y، وآخرون (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. ج. 407 ع. 6803: 530–5. DOI:10.1038/35035117. PMID:11029007.
Mao B، Wu W، Li Y، وآخرون (2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. ج. 411 ع. 6835: 321–5. DOI:10.1038/35077108. PMID:11357136.
Semënov MV، Tamai K، Brott BK، وآخرون (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. ج. 11 ع. 12: 951–61. DOI:10.1016/S0960-9822(01)00290-1. PMID:11448771.
Li L، Mao J، Sun L، وآخرون (2002). "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled". J. Biol. Chem. ج. 277 ع. 8: 5977–81. DOI:10.1074/jbc.M111131200. PMID:11742004.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Caricasole A، Ferraro T، Iacovelli L، وآخرون (2003). "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins". J. Biol. Chem. ج. 278 ع. 39: 37024–31. DOI:10.1074/jbc.M300191200. PMID:12857724.
Liu G، Bafico A، Harris VK، Aaronson SA (2003). "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor". Mol. Cell. Biol. ج. 23 ع. 16: 5825–35. DOI:10.1128/MCB.23.16.5825-5835.2003. PMC:166321. PMID:12897152.
Zilberberg A، Yaniv A، Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". J. Biol. Chem. ج. 279 ع. 17: 17535–42. DOI:10.1074/jbc.M311292200. PMID:14739301.
Wang X، Adhikari N، Li Q، Hall JL (2005). "LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells". Am. J. Physiol. Heart Circ. Physiol. ج. 287 ع. 6: H2376–83. DOI:10.1152/ajpheart.01173.2003. PMID:15271658.
Suzuki Y، Yamashita R، Shirota M، وآخرون (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. ج. 14 ع. 9: 1711–8. DOI:10.1101/gr.2435604. PMC:515316. PMID:15342556.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Li Y، Lu W، He X، وآخرون (2005). "LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution". Oncogene. ج. 23 ع. 56: 9129–35. DOI:10.1038/sj.onc.1208123. PMID:15516984.
Semënov M، Tamai K، He X (2005). "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor". J. Biol. Chem. ج. 280 ع. 29: 26770–5. DOI:10.1074/jbc.M504308200. PMID:15908424.
Li Y، Chen J، Lu W، وآخرون (2006). "Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding". J. Cell Sci. ج. 118 ع. Pt 22: 5305–14. DOI:10.1242/jcs.02651. PMID:16263759.
Mi K، Dolan PJ، Johnson GV (2006). "The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity". J. Biol. Chem. ج. 281 ع. 8: 4787–94. DOI:10.1074/jbc.M508657200. PMID:16365045.

هذه بذرة مقالة عن جين على كروموسوم 12 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6". مؤرشف من الأصل في 2010-12-05.

[pmid9704021-2] Brown SD، Twells RC، Hey PJ، Cox RD، Levy ER، Soderman AR، Metzker ML، Caskey CT، Todd JA، Hess JF (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem. Biophys. Res. Commun. ج. 248 ع. 3: 879–88. DOI:10.1006/bbrc.1998.9061. PMID:9704021.

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