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ARHGEF12
An Error has occured retrieving Wikidata item for infobox ARHGEF12 (Rho guanine nucleotide exchange factor 12) هوَ بروتين يُشَفر بواسطة جين ARHGEF12 في الإنسان.[1][2][3]
الوظيفة
![[أيقونة]](/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
- ^ Nagase T، Ishikawa K، Nakajima D، Ohira M، Seki N، Miyajima N، Tanaka A، Kotani H، Nomura N، Ohara O (سبتمبر 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. ج. 4 ع. 2: 141–50. DOI:10.1093/dnares/4.2.141. PMID:9205841.
- ^ "Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12". مؤرشف من الأصل في 2010-12-05.
- ^ Kourlas PJ، Strout MP، Becknell B، Veronese ML، Croce CM، Theil KS، Krahe R، Ruutu T، Knuutila S، Bloomfield CD، Caligiuri MA (أبريل 2000). "Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia". Proc Natl Acad Sci U S A. ج. 97 ع. 5: 2145–50. DOI:10.1073/pnas.040569197. PMC:15768. PMID:10681437.
قراءة متعمقة
- Fukuhara S، Chikumi H، Gutkind JS (2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. ج. 485 ع. 2–3: 183–8. DOI:10.1016/S0014-5793(00)02224-9. PMID:11094164.
- Reuther GW، Lambert QT، Booden MA، وآخرون (2001). "Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA". J. Biol. Chem. ج. 276 ع. 29: 27145–51. DOI:10.1074/jbc.M103565200. PMID:11373293.
- Taya S، Inagaki N، Sengiku H، وآخرون (2002). "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF". J. Cell Biol. ج. 155 ع. 5: 809–20. DOI:10.1083/jcb.200106139. PMC:2150867. PMID:11724822.
- Chikumi H، Fukuhara S، Gutkind JS (2002). "Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase". J. Biol. Chem. ج. 277 ع. 14: 12463–73. DOI:10.1074/jbc.M108504200. PMID:11799111.
- Perrot V، Vazquez-Prado J، Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. ج. 277 ع. 45: 43115–20. DOI:10.1074/jbc.M206005200. PMID:12183458.
- Aurandt J، Vikis HG، Gutkind JS، وآخرون (2002). "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 19: 12085–90. DOI:10.1073/pnas.142433199. PMC:129402. PMID:12196628.
- Hirotani M، Ohoka Y، Yamamoto T، وآخرون (2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. ج. 297 ع. 1: 32–7. DOI:10.1016/S0006-291X(02)02122-8. PMID:12220504.
- Driessens MH، Olivo C، Nagata K، وآخرون (2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Lett. ج. 529 ع. 2–3: 168–72. DOI:10.1016/S0014-5793(02)03323-9. PMID:12372594.
- Wennerberg K، Ellerbroek SM، Liu RY، وآخرون (2003). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. ج. 277 ع. 49: 47810–7. DOI:10.1074/jbc.M203816200. PMID:12376551.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Suzuki N، Nakamura S، Mano H، Kozasa T (2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. ج. 100 ع. 2: 733–8. DOI:10.1073/pnas.0234057100. PMC:141065. PMID:12515866.
- Chikumi H، Barac A، Behbahani B، وآخرون (2004). "Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential". Oncogene. ج. 23 ع. 1: 233–40. DOI:10.1038/sj.onc.1207012. PMID:14712228.
- Wang Q، Liu M، Kozasa T، وآخرون (2004). "Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells". J. Biol. Chem. ج. 279 ع. 28: 28831–4. DOI:10.1074/jbc.C400105200. PMID:15143072.
- Kristelly R، Gao G، Tesmer JJ (2004). "Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor". J. Biol. Chem. ج. 279 ع. 45: 47352–62. DOI:10.1074/jbc.M406056200. PMID:15331592.
- Ballif BA، Villén J، Beausoleil SA، وآخرون (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. ج. 3 ع. 11: 1093–101. DOI:10.1074/mcp.M400085-MCP200. PMID:15345747.
- Okuhira K، Fitzgerald ML، Sarracino DA، وآخرون (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. ج. 280 ع. 47: 39653–64. DOI:10.1074/jbc.M510187200. PMID:16192269.
- Goto M، Muramatsu H، Mihara H، وآخرون (2006). "Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction". J. Biol. Chem. ج. 280 ع. 49: 40875–84. DOI:10.1074/jbc.M507399200. PMID:16192274.
- Bourguignon LY، Gilad E، Brightman A، وآخرون (2006). "Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells". J. Biol. Chem. ج. 281 ع. 20: 14026–40. DOI:10.1074/jbc.M507734200. PMID:16565089.
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