SUB1

An Error has occured retrieving Wikidata item for infobox SUB1‏ (SUB1 homolog, transcriptional regulator) هوَ بروتين يُشَفر بواسطة جين SUB1 في الإنسان.^[1]^[2]^[2]^[3]^[4]

الوظيفة

الأهمية السريرية

المراجع

^ Ge H، Roeder RG (أغسطس 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell. ج. 78 ع. 3: 513–23. DOI:10.1016/0092-8674(94)90428-6. PMID:8062391.
^ ^أ ^ب "Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)". مؤرشف من الأصل في 2010-12-05.
^ Knaus R، Pollock R، Guarente L (أبريل 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. ج. 15 ع. 8: 1933–40. PMC:450112. PMID:8617240.
^ Kretzschmar M، Kaiser K، Lottspeich F، Meisterernst M (أغسطس 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell. ج. 78 ع. 3: 525–34. DOI:10.1016/0092-8674(94)90429-4. PMID:8062392.

قراءة متعمقة

Kaiser K، Stelzer G، Meisterernst M (يوليو 1995). "The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation". The EMBO Journal. ج. 14 ع. 14: 3520–7. PMC:394420. PMID:7628453.
Ge H، Zhao Y، Chait BT، Roeder RG (ديسمبر 1994). "Phosphorylation negatively regulates the function of coactivator PC4". Proceedings of the National Academy of Sciences of the United States of America. ج. 91 ع. 26: 12691–5. DOI:10.1073/pnas.91.26.12691. PMC:45505. PMID:7809103.
Brandsen J، Werten S، van der Vliet PC، Meisterernst M، Kroon J، Gros P (نوفمبر 1997). "C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site". Nature Structural Biology. ج. 4 ع. 11: 900–3. DOI:10.1038/nsb1197-900. PMID:9360603.
Malik S، Guermah M، Roeder RG (مارس 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proceedings of the National Academy of Sciences of the United States of America. ج. 95 ع. 5: 2192–7. DOI:10.1073/pnas.95.5.2192. PMC:19292. PMID:9482861.
Luo Y، Ge H، Stevens S، Xiao H، Roeder RG (يوليو 1998). "Coactivation by OCA-B: definition of critical regions and synergism with general cofactors". Molecular and Cellular Biology. ج. 18 ع. 7: 3803–10. DOI:10.1128/mcb.18.7.3803. PMC:108964. PMID:9632764.
Currie RA (يوليو 1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development". The Journal of Biological Chemistry. ج. 273 ع. 29: 18220–9. DOI:10.1074/jbc.273.29.18220. PMID:9660784.
Wang Z، Roeder RG (أبريل 1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Molecular Cell. ج. 1 ع. 5: 749–57. DOI:10.1016/S1097-2765(00)80074-X. PMID:9660958.
Holloway AF، Occhiodoro F، Mittler G، Meisterernst M، Shannon MF (يوليو 2000). "Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells". The Journal of Biological Chemistry. ج. 275 ع. 28: 21668–77. DOI:10.1074/jbc.M909058199. PMID:10887206.
Yuan CX، Gurley WB (يوليو 2000). "Potential targets for HSF1 within the preinitiation complex". Cell Stress & Chaperones. ج. 5 ع. 3: 229–42. DOI:10.1379/1466-1268(2000)005<0229:PTFHWT>2.0.CO;2. PMC:312889. PMID:11005381.
Kumar BR، Swaminathan V، Banerjee S، Kundu TK (مايو 2001). "p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation". The Journal of Biological Chemistry. ج. 276 ع. 20: 16804–9. DOI:10.1074/jbc.M100934200. PMID:11279157.
Yu P، Huang B، Shen M، Lau C، Chan E، Michel J، Xiong Y، Payan DG، Luo Y (يناير 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. ج. 20 ع. 4: 484–9. DOI:10.1038/sj.onc.1204113. PMID:11313979.
Calvo O، Manley JL (مايو 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Molecular Cell. ج. 7 ع. 5: 1013–23. DOI:10.1016/S1097-2765(01)00236-2. PMID:11389848.
Guo H، Cai CQ، Kuo PC (فبراير 2002). "Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription". The Journal of Biological Chemistry. ج. 277 ع. 7: 5054–60. DOI:10.1074/jbc.M109017200. PMID:11741883.
Dubois T، Zemlickova E، Howell S، Aitken A (فبراير 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications. ج. 301 ع. 2: 502–8. DOI:10.1016/S0006-291X(02)03010-3. PMID:12565890.
Fukuda A، Tokonabe S، Hamada M، Matsumoto M، Tsukui T، Nogi Y، Hisatake K (أبريل 2003). "Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH". The Journal of Biological Chemistry. ج. 278 ع. 17: 14827–31. DOI:10.1074/jbc.M213172200. PMID:12590132.
Swietlicki E، Iordanov H، Fritsch C، Yi L، Levin MS، Rubin DC (2003). "Growth factor regulation of PC4/TIS7, an immediate early gene expressed during gut adaptation after resection". JPEN. Journal of Parenteral and Enteral Nutrition. ج. 27 ع. 2: 123–31. DOI:10.1177/0148607103027002123. PMID:12665168.
Banerjee S، Kumar BR، Kundu TK (مارس 2004). "General transcriptional coactivator PC4 activates p53 function". Molecular and Cellular Biology. ج. 24 ع. 5: 2052–62. DOI:10.1128/MCB.24.5.2052-2062.2004. PMC:350566. PMID:14966284.
Caldwell RB، Braselmann H، Schoetz U، Heuer S، Scherthan H، Zitzelsberger H (يوليو 2016). "Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells". Sci. Rep. ج. 6: 28890. DOI:10.1038/srep28890. PMC:4931448. PMID:27374870.

هذه بذرة مقالة عن جين على كروموسوم 5 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid8062391-1] Ge H، Roeder RG (أغسطس 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell. ج. 78 ع. 3: 513–23. DOI:10.1016/0092-8674(94)90428-6. PMID:8062391.

[entrez-2] أ ^ب "Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)". مؤرشف من الأصل في 2010-12-05.

[pmid8617240-3] Knaus R، Pollock R، Guarente L (أبريل 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. ج. 15 ع. 8: 1933–40. PMC:450112. PMID:8617240.

[pmid8062392-4] Kretzschmar M، Kaiser K، Lottspeich F، Meisterernst M (أغسطس 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell. ج. 78 ع. 3: 525–34. DOI:10.1016/0092-8674(94)90429-4. PMID:8062392.

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