GZMA

An Error has occured retrieving Wikidata item for infobox GZMA‏ (Granzyme A) هوَ بروتين يُشَفر بواسطة جين GZMA في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Masson D، Zamai M، Tschopp J (ديسمبر 1986). "Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes". FEBS Lett. ج. 208 ع. 1: 84–8. DOI:10.1016/0014-5793(86)81537-X. PMID:3533635.
^ "Entrez Gene: GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)". مؤرشف من الأصل في 2010-12-05.
^ Hameed A، Lowrey DM، Lichtenheld M، Podack ER (نوفمبر 1988). "Characterization of three serine esterases isolated from human IL-2 activated killer cells". J Immunol. ج. 141 ع. 9: 3142–7. PMID:3262682.

قراءة متعمقة

Pasternack MS، Bleier KJ، McInerney TN (1991). "Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro". J. Biol. Chem. ج. 266 ع. 22: 14703–8. PMID:1860869.
Poe M، Bennett CD، Biddison WE، وآخرون (1988). "Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity". J. Biol. Chem. ج. 263 ع. 26: 13215–22. PMID:3047119.
Murphy ME، Moult J، Bleackley RC، وآخرون (1989). "Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes". Proteins. ج. 4 ع. 3: 190–204. DOI:10.1002/prot.340040306. PMID:3237717.
Gershenfeld HK، Hershberger RJ، Shows TB، Weissman IL (1988). "Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease". Proc. Natl. Acad. Sci. U.S.A. ج. 85 ع. 4: 1184–8. DOI:10.1073/pnas.85.4.1184. PMC:279731. PMID:3257574.
Krähenbühl O، Rey C، Jenne D، وآخرون (1988). "Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes". J. Immunol. ج. 141 ع. 10: 3471–7. PMID:3263427.
Baetz K، Isaaz S، Griffiths GM (1995). "Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis". J. Immunol. ج. 154 ع. 11: 6122–31. PMID:7751653.
Inoue M، Hoshino T، Fukuma T، وآخرون (1994). "Close co-localization of CD4 and a serine esterase tryptase TL2 on the cell-surface of human monocytoid and CD4+ lymphoid cells". Biochem. Biophys. Res. Commun. ج. 201 ع. 3: 1390–5. DOI:10.1006/bbrc.1994.1857. PMID:7912927.
Fink TM، Lichter P، Wekerle H، وآخرون (1994). "The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily". Genomics. ج. 18 ع. 2: 401–3. DOI:10.1006/geno.1993.1483. PMID:8288245.
Beresford PJ، Kam CM، Powers JC، Lieberman J (1997). "Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them". Proc. Natl. Acad. Sci. U.S.A. ج. 94 ع. 17: 9285–90. DOI:10.1073/pnas.94.17.9285. PMC:23158. PMID:9256474.
Spaeny-Dekking EH، Hanna WL، Wolbink AM، وآخرون (1998). "Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo". J. Immunol. ج. 160 ع. 7: 3610–6. PMID:9531325.
Zhang D، Beresford PJ، Greenberg AH، Lieberman J (2001). "Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis". Proc. Natl. Acad. Sci. U.S.A. ج. 98 ع. 10: 5746–51. DOI:10.1073/pnas.101329598. PMC:33284. PMID:11331782.
Beresford PJ، Zhang D، Oh DY، وآخرون (2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". J. Biol. Chem. ج. 276 ع. 46: 43285–93. DOI:10.1074/jbc.M108137200. PMID:11555662.
Fan Z، Beresford PJ، Zhang D، Lieberman J (2002). "HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A". Mol. Cell. Biol. ج. 22 ع. 8: 2810–20. DOI:10.1128/MCB.22.8.2810-2820.2002. PMC:133744. PMID:11909973.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Fan Z، Beresford PJ، Zhang D، وآخرون (2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A". Nat. Immunol. ج. 4 ع. 2: 145–53. DOI:10.1038/ni885. PMID:12524539.
Pinkoski MJ، Green DR (2003). "Granzyme A: the road less traveled". Nat. Immunol. ج. 4 ع. 2: 106–8. DOI:10.1038/ni0203-106. PMID:12555094.
Saito S، Iida A، Sekine A، وآخرون (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. ج. 48 ع. 5: 249–70. DOI:10.1007/s10038-003-0021-7. PMID:12721789.
Bell JK، Goetz DH، Mahrus S، وآخرون (2003). "The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity". Nat. Struct. Biol. ج. 10 ع. 7: 527–34. DOI:10.1038/nsb944. PMID:12819769.

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[1] Masson D، Zamai M، Tschopp J (ديسمبر 1986). "Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes". FEBS Lett. ج. 208 ع. 1: 84–8. DOI:10.1016/0014-5793(86)81537-X. PMID:3533635.

[2] "Entrez Gene: GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)". مؤرشف من الأصل في 2010-12-05.

[3] Hameed A، Lowrey DM، Lichtenheld M، Podack ER (نوفمبر 1988). "Characterization of three serine esterases isolated from human IL-2 activated killer cells". J Immunol. ج. 141 ع. 9: 3142–7. PMID:3262682.

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