PRKRA

An Error has occured retrieving Wikidata item for infobox PRKRA‏ (Protein activator of interferon induced protein kinase EIF2AK2) هوَ بروتين يُشَفر بواسطة جين PRKRA في الإنسان.^[1]^[1]^[2]^[3]^[4]^[5]

الوظيفة

الأهمية السريرية

المراجع

^ ^أ ^ب Patel RC، Sen GC (أغسطس 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". EMBO J. ج. 17 ع. 15: 4379–90. DOI:10.1093/emboj/17.15.4379. PMC:1170771. PMID:9687506.
^ Camargos S، Scholz S، Simón-Sánchez J، Paisán-Ruiz C، Lewis P، Hernandez D، Ding J، Gibbs JR، Cookson MR، Bras J، Guerreiro R، Oliveira CR، Lees A، Hardy J، Cardoso F، Singleton AB (مارس 2008). "DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA". Lancet Neurology. ج. 7 ع. 3: 207–215. DOI:10.1016/S1474-4422(08)70022-X. PMID:18243799.
^ Huang X، Hutchins B، Patel RC (أغسطس 2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. ج. 366 ع. Pt 1: 175–86. DOI:10.1042/BJ20020204. PMC:1222748. PMID:11985496.
^ Ito T، Yang M، May WS (مايو 1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling". J. Biol. Chem. ج. 274 ع. 22: 15427–32. DOI:10.1074/jbc.274.22.15427. PMID:10336432.
^ "Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator". مؤرشف من الأصل في 2010-12-05.

قراءة متعمقة

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Peters GA، Hartmann R، Qin J، وآخرون (2001). "Modular structure of PACT: distinct domains for binding and activating PKR". Mol Cell Biol. ج. 21 ع. 6: 1908–20. DOI:10.1128/MCB.21.6.1908-1920.2001. PMC:86773. PMID:11238927.
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Huang X، Hutchins B، Patel RC (2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. ج. 366 ع. Pt 1: 175–86. DOI:10.1042/BJ20020204. PMC:1222748. PMID:11985496.
Peters GA، Khoo D، Mohr I، Sen GC (2002). "Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein". J. Virol. ج. 76 ع. 21: 11054–64. DOI:10.1128/JVI.76.21.11054-11064.2002. PMC:136652. PMID:12368348.
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Yang M، Ito T، May WS (2003). "A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression". J. Biol. Chem. ج. 278 ع. 40: 38325–32. DOI:10.1074/jbc.M303420200. PMID:12874289.
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Bennett RL، Blalock WL، May WS (2004). "Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition". J. Biol. Chem. ج. 279 ع. 41: 42687–93. DOI:10.1074/jbc.M403321200. PMID:15299031.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Hillier LW، Graves TA، Fulton RS، وآخرون (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. ج. 434 ع. 7034: 724–31. DOI:10.1038/nature03466. PMID:15815621.
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Rual JF، Venkatesan K، Hao T، وآخرون (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. ج. 437 ع. 7062: 1173–8. DOI:10.1038/nature04209. PMID:16189514.
Peters GA، Li S، Sen GC (2006). "Phosphorylation of specific serine residues in the PKR-activation domain of PACT is essential for its ability to mediate apoptosis". J Biol Chem. ج. 281 ع. 46: 35129–36. DOI:10.1074/jbc.M607714200. PMID:16982605.
Rowe TM، Rizzi M، Hirose K، Peters GA، وآخرون (2006). "A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing". Proc Natl Acad Sci USA. ج. 103 ع. 15: 5823–8. DOI:10.1073/pnas.0601287103. PMC:1458657. PMID:16571658.
Li S، Peters GA، Ding K، وآخرون (2006). "Molecular basis for PKR activation by PACT or dsRNA". Proc Natl Acad Sci USA. ج. 103 ع. 26: 10005–10. DOI:10.1073/pnas.0602317103. PMC:1502496. PMID:16785445.
Lee Y، Hur I، Park SY، وآخرون (2006). "The role of PACT in the RNA silencing pathway". EMBO J. ج. 25 ع. 3: 522–32. DOI:10.1038/sj.emboj.7600942. PMC:1383527. PMID:16424907.
Bennett RL، Blalock WL، Abtahi DM، وآخرون (2006). "RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection". Blood. ج. 108 ع. 3: 821–9. DOI:10.1182/blood-2005-11-006817. PMC:1617065. PMID:16861340.
Peters GA، Seachrist DD، Keri RA، وآخرون (2009). "The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation". Proc Natl Acad Sci USA. ج. 106 ع. 26: 10696–701. DOI:10.1073/pnas.0900735106. PMC:2705576. PMID:19541653.

هذه بذرة مقالة عن جين على كروموسوم 2 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid9687506-1] أ ^ب Patel RC، Sen GC (أغسطس 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". EMBO J. ج. 17 ع. 15: 4379–90. DOI:10.1093/emboj/17.15.4379. PMC:1170771. PMID:9687506.

[pmid18243799-2] Camargos S، Scholz S، Simón-Sánchez J، Paisán-Ruiz C، Lewis P، Hernandez D، Ding J، Gibbs JR، Cookson MR، Bras J، Guerreiro R، Oliveira CR، Lees A، Hardy J، Cardoso F، Singleton AB (مارس 2008). "DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA". Lancet Neurology. ج. 7 ع. 3: 207–215. DOI:10.1016/S1474-4422(08)70022-X. PMID:18243799.

[pmid11985496-3] Huang X، Hutchins B، Patel RC (أغسطس 2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. ج. 366 ع. Pt 1: 175–86. DOI:10.1042/BJ20020204. PMC:1222748. PMID:11985496.

[pmid10336432-4] Ito T، Yang M، May WS (مايو 1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling". J. Biol. Chem. ج. 274 ع. 22: 15427–32. DOI:10.1074/jbc.274.22.15427. PMID:10336432.

[entrez-5] "Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator". مؤرشف من الأصل في 2010-12-05.

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