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REL
An Error has occured retrieving Wikidata item for infobox REL (REL proto-oncogene, NF-kB subunit) هوَ بروتين يُشَفر بواسطة جين REL في الإنسان.[1][2]
الوظيفة
![[أيقونة]](/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
- ^ Gilmore TD، Kalaitzidis D، Liang MC، Starczynowski DT (مارس 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. ج. 23 ع. 13: 2275–86. DOI:10.1038/sj.onc.1207410. PMID:14755244.
- ^ Ruben SM، Klement JF، Coleman TA، Maher M، Chen CH، Rosen CA (يونيو 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. ج. 6 ع. 5: 745–60. DOI:10.1101/gad.6.5.745. PMID:1577270.
قراءة متعمقة
- Rayet B، Gélinas C (2000). "Aberrant rel/nfkb genes and activity in human cancer". Oncogene. ج. 18 ع. 49: 6938–47. DOI:10.1038/sj.onc.1203221. PMID:10602468.
- Kunsch C، Ruben SM، Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation". Mol. Cell. Biol. ج. 12 ع. 10: 4412–21. PMC:360365. PMID:1406630.
- Neumann M، Tsapos K، Scheppler JA، وآخرون (1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene. ج. 7 ع. 11: 2095–104. PMID:1437141.
- Kochel T، Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro". Oncogene. ج. 7 ع. 3: 567–72. PMID:1549370.
- Kumar S، Rabson AB، Gélinas C (1992). "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein". Mol. Cell. Biol. ج. 12 ع. 7: 3094–106. PMC:364524. PMID:1620118.
- Lu D، Thompson JD، Gorski GK، وآخرون (1991). "Alterations at the rel locus in human lymphoma". Oncogene. ج. 6 ع. 7: 1235–41. PMID:1650444.
- Muchardt C، Seeler JS، Nirula A، وآخرون (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. ج. 66 ع. 1: 244–50. PMC:238281. PMID:1727488.
- Hansen SK، Nerlov C، Zabel U، وآخرون (1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene". EMBO J. ج. 11 ع. 1: 205–13. PMC:556441. PMID:1740106.
- Davis N، Ghosh S، Simmons DL، وآخرون (1991). "Rel-associated pp40: an inhibitor of the rel family of transcription factors". Science. ج. 253 ع. 5025: 1268–71. DOI:10.1126/science.1891714. PMID:1891714.
- Lim MY، Davis N، Zhang JY، Bose HR (1990). "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70". Virology. ج. 175 ع. 1: 149–60. DOI:10.1016/0042-6822(90)90195-W. PMID:2155506.
- Brownell E، Mittereder N، Rice NR (1989). "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon". Oncogene. ج. 4 ع. 7: 935–42. PMID:2666912.
- Brownell E، O'Brien SJ، Nash WG، Rice N (1986). "Genetic characterization of human c-rel sequences". Mol. Cell. Biol. ج. 5 ع. 10: 2826–31. PMC:367021. PMID:3016517.
- Brownell E، Kozak CA، Fowle JR، وآخرون (1986). "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat". Am. J. Hum. Genet. ج. 39 ع. 2: 194–202. PMC:1683919. PMID:3529946.
- John S، Reeves RB، Lin JX، وآخرون (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins". Mol. Cell. Biol. ج. 15 ع. 3: 1786–96. DOI:10.1128/mcb.15.3.1786. PMC:230403. PMID:7862168.
- Xu X، Gélinas C (1995). "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells". Virology. ج. 207 ع. 2: 362–8. DOI:10.1006/viro.1995.1095. PMID:7886940.
- Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers". J. Biol. Chem. ج. 269 ع. 42: 26363–7. PMID:7929355.
- Sif S، Gilmore TD (1994). "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1". J. Virol. ج. 68 ع. 11: 7131–8. PMC:237152. PMID:7933095.
- Hansen SK، Baeuerle PA، Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription". Mol. Cell. Biol. ج. 14 ع. 4: 2593–603. DOI:10.1128/mcb.14.4.2593. PMC:358627. PMID:8139561.
- Beg AA، Baldwin AS (1994). "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor". Oncogene. ج. 9 ع. 5: 1487–92. PMID:8152812.
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