EIF2B4

An Error has occured retrieving Wikidata item for infobox EIF2B4‏ (Eukaryotic translation initiation factor 2B subunit delta) هوَ بروتين يُشَفر بواسطة جين EIF2B4 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa". مؤرشف من الأصل في 2010-03-07.
^ Henderson RA، Krissansen GW، Yong RY، Leung E، Watson JD، Dholakia JN (ديسمبر 1994). "The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end". J. Biol. Chem. ج. 269 ع. 48: 30517–23. PMID:7982969.
^ Price NT، Mellor H، Craddock BL، Flowers KM، Kimball SR، Wilmer T، Jefferson LS، Proud CG (نوفمبر 1996). "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast". Biochem. J. ج. 318 ع. 2: 637–43. PMC:1217679. PMID:8929216.

قراءة متعمقة

Welsh GI، Miyamoto S، Price NT، وآخرون (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. ج. 271 ع. 19: 11410–3. DOI:10.1074/jbc.271.19.11410. PMID:8626696.
Yang W، Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol. Cell. Biol. ج. 16 ع. 11: 6603–16. PMC:231662. PMID:8887689.
Kimball SR، Heinzinger NK، Horetsky RL، Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. ج. 273 ع. 5: 3039–44. DOI:10.1074/jbc.273.5.3039. PMID:9446619.
Gomez E، Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Mol. Cell. Biol. ج. 20 ع. 11: 3965–76. DOI:10.1128/MCB.20.11.3965-3976.2000. PMC:85753. PMID:10805739.
Anthony TG، Fabian JR، Kimball SR، Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. ج. 1492 ع. 1: 56–62. DOI:10.1016/S0167-4781(00)00062-2. PMID:10858531.
Hu RM، Han ZG، Song HD، وآخرون (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 17: 9543–8. DOI:10.1073/pnas.160270997. PMC:16901. PMID:10931946.
Williams DD، Price NT، Loughlin AJ، Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. ج. 276 ع. 27: 24697–703. DOI:10.1074/jbc.M011788200. PMID:11323413.
van der Knaap MS، Leegwater PA، Könst AA، وآخرون (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. ج. 51 ع. 2: 264–70. DOI:10.1002/ana.10112. PMID:11835386.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Fogli A، Dionisi-Vici C، Deodato F، وآخرون (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. ج. 59 ع. 12: 1966–8. DOI:10.1212/01.wnl.0000041666.76863.47. PMID:12499492.
Kobayashi H، Børsheim E، Anthony TG، وآخرون (2003). "Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B". Am. J. Physiol. Endocrinol. Metab. ج. 284 ع. 3: E488–98. DOI:10.1152/ajpendo.00094.2002. PMID:12556349.
Fogli A، Rodriguez D، Eymard-Pierre E، وآخرون (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. ج. 72 ع. 6: 1544–50. DOI:10.1086/375404. PMC:1180314. PMID:12707859.
van der Knaap MS، van Berkel CG، Herms J، وآخرون (2004). "eIF2B-related disorders: antenatal onset and involvement of multiple organs". Am. J. Hum. Genet. ج. 73 ع. 5: 1199–207. DOI:10.1086/379524. PMC:1180499. PMID:14566705.
Fogli A، Schiffmann R، Hugendubler L، وآخرون (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. ج. 12 ع. 7: 561–6. DOI:10.1038/sj.ejhg.5201189. PMID:15054402.
Li W، Wang X، Van Der Knaap MS، Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways". Mol. Cell. Biol. ج. 24 ع. 8: 3295–306. DOI:10.1128/MCB.24.8.3295-3306.2004. PMC:381664. PMID:15060152.
Van Haren K، van der Voorn JP، Peterson DR، وآخرون (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. ج. 63 ع. 6: 618–30. PMID:15217090.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Fogli A، Gauthier-Barichard F، Schiffmann R، وآخرون (2004). "Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure". BMC Women's Health. ج. 4 ع. 1: 8. DOI:10.1186/1472-6874-4-8. PMC:529454. PMID:15507143.

هذه بذرة مقالة عن جين على كروموسوم 2 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa". مؤرشف من الأصل في 2010-03-07.

[pmid7982969-2] Henderson RA، Krissansen GW، Yong RY، Leung E، Watson JD، Dholakia JN (ديسمبر 1994). "The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end". J. Biol. Chem. ج. 269 ع. 48: 30517–23. PMID:7982969.

[pmid8929216-3] Price NT، Mellor H، Craddock BL، Flowers KM، Kimball SR، Wilmer T، Jefferson LS، Proud CG (نوفمبر 1996). "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast". Biochem. J. ج. 318 ع. 2: 637–43. PMC:1217679. PMID:8929216.

[1]

[2]

[3]