CLCA1

An Error has occured retrieving Wikidata item for infobox CLCA1‏ (Chloride channel accessory 1) هوَ بروتين يُشَفر بواسطة جين CLCA1 في الإنسان.^[1]

الوظيفة

الأهمية السريرية

المراجع

^ Gruber AD، Elble RC، Ji HL، Schreur KD، Fuller CM، Pauli BU (يناير 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics. ج. 54 ع. 2: 200–14. DOI:10.1006/geno.1998.5562. PMID:9828122.

قراءة متعمقة

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Pauli BU، Abdel-Ghany M، Cheng HC، وآخرون (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. ج. 27 ع. 11: 901–5. DOI:10.1046/j.1440-1681.2000.03358.x. PMID:11071307.
Agnel M، Vermat T، Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. ج. 455 ع. 3: 295–301. DOI:10.1016/S0014-5793(99)00891-1. PMID:10437792.
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Toda M، Tulic MK، Levitt RC، Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. ج. 109 ع. 2: 246–50. DOI:10.1067/mai.2002.121555. PMID:11842292.
Greenwood IA، Miller LJ، Ohya S، Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. ج. 277 ع. 25: 22119–22. DOI:10.1074/jbc.C200215200. PMID:11994272.
Abdel-Ghany M، Cheng HC، Elble RC، Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. ج. 277 ع. 37: 34391–400. DOI:10.1074/jbc.M205307200. PMID:12110680.
Loewen ME، Bekar LK، Gabriel SE، وآخرون (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. ج. 298 ع. 4: 531–6. DOI:10.1016/S0006-291X(02)02498-1. PMID:12408984.
Zhou Y، Shapiro M، Dong Q، وآخرون (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Novartis Found. Symp. ج. 248: 150–65, discussion 165–70, 277–82. DOI:10.1002/0470860790.ch10. PMID:12568493.
Abdel-Ghany M، Cheng HC، Elble RC، وآخرون (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. ج. 278 ع. 49: 49406–16. DOI:10.1074/jbc.M309086200. PMID:14512419.
Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
Hegab AE، Sakamoto T، Uchida Y، وآخرون (2004). "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease". J. Med. Genet. ج. 41 ع. 3: e27. DOI:10.1136/jmg.2003.012484. PMC:1735703. PMID:14985398.
Kamada F، Suzuki Y، Shao C، وآخرون (2005). "Association of the hCLCA1 gene with childhood and adult asthma". Genes Immun. ج. 5 ع. 7: 540–7. DOI:10.1038/sj.gene.6364124. PMID:15318163.
Ritzka M، Stanke F، Jansen S، وآخرون (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. ج. 115 ع. 6: 483–91. DOI:10.1007/s00439-004-1190-y. PMID:15490240.
Gibson A، Lewis AP، Affleck K، وآخرون (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. ج. 280 ع. 29: 27205–12. DOI:10.1074/jbc.M504654200. PMID:15919655.
Jeong SM، Park HK، Yoon IS، وآخرون (2005). "Cloning and expression of Ca²⁺-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. ج. 334 ع. 2: 569–76. DOI:10.1016/j.bbrc.2005.06.122. PMID:16023076.

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[pmid9828122-1] Gruber AD، Elble RC، Ji HL، Schreur KD، Fuller CM، Pauli BU (يناير 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics. ج. 54 ع. 2: 200–14. DOI:10.1006/geno.1998.5562. PMID:9828122.

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