CAPN2

An Error has occured retrieving Wikidata item for infobox CAPN2‏ (Calpain 2) هوَ بروتين يُشَفر بواسطة جين CAPN2 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ Hata A، Ohno S، Akita Y، Suzuki K (مايو 1989). "Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease". J. Biol. Chem. ج. 264 ع. 11: 6404–11. PMID:2539381.
^ Imajoh S، Aoki K، Ohno S، Emori Y، Kawasaki H، Sugihara H، Suzuki K (1988). "Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease". Biochemistry. ج. 27 ع. 21: 8122–8. DOI:10.1021/bi00421a022. PMID:2852952.

قراءة متعمقة

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Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. ج. 326 ع. Pt 1: 1–16. DOI:10.1042/bj3260001. PMC:1218630. PMID:9337844.
Reverter D، Sorimachi H، Bode W (2001). "The structure of calcium-free human m-calpain: implications for calcium activation and function". Trends Cardiovasc. Med. ج. 11 ع. 6: 222–9. DOI:10.1016/S1050-1738(01)00112-8. PMID:11673052.
Kopp S (1976). "Reproducibility of response to a questionnaire on symptoms of masticatory dysfunction". Community Dent Oral Epidemiol. ج. 4 ع. 5: 205–9. DOI:10.1111/j.1600-0528.1976.tb00985.x. PMID:1067155.
Adachi Y، Kitahara-Ozawa A، Sugamura K، Lee WJ، Yodoi J، Maki M، Murachi T، Hatanaka M (1992). "Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I". J. Biol. Chem. ج. 267 ع. 27: 19373–8. PMID:1527057.
Ohno S، Minoshima S، Kudoh J، Fukuyama R، Shimizu Y، Ohmi-Imajoh S، Shimizu N، Suzuki K (1990). "Four genes for the calpain family locate on four distinct human chromosomes". Cytogenet. Cell Genet. ج. 53 ع. 4: 225–9. DOI:10.1159/000132937. PMID:2209092.
Ishiguro H، Higashiyama S، Namikawa C، Kunimatsu M، Takano E، Tanaka K، Ohkubo I، Murachi T، Sasaki M (1987). "Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations". Biochemistry. ج. 26 ع. 10: 2863–70. DOI:10.1021/bi00384a030. PMID:3038169.
Srinivasula SM، Fernandes-Alnemri T، Zangrilli J، Robertson N، Armstrong RC، Wang L، Trapani JA، Tomaselli KJ، Litwack G، Alnemri ES (1996). "The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32". J. Biol. Chem. ج. 271 ع. 43: 27099–106. DOI:10.1074/jbc.271.43.27099. PMID:8900201.
Corasaniti MT، Navarra M، Catani MV، Melino G، Nisticò G، Finazzi-Agrò A (1996). "NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain". Biochem. Biophys. Res. Commun. ج. 229 ع. 1: 299–304. DOI:10.1006/bbrc.1996.1796. PMID:8954122.
Fujitani K، Kambayashi J، Sakon M، Ohmi SI، Kawashima S، Yukawa M، Yano Y، Miyoshi H، Ikeda M، Shinoki N، Monden M (1997). "Identification of mu-, m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells". J. Cell. Biochem. ج. 66 ع. 2: 197–209. DOI:10.1002/(SICI)1097-4644(19970801)66:2<197::AID-JCB7>3.0.CO;2-L. PMID:9213221.
Rock MT، Brooks WH، Roszman TL (1997). "Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events". J. Biol. Chem. ج. 272 ع. 52: 33377–83. DOI:10.1074/jbc.272.52.33377. PMID:9407132.
Ueyama H، Kumamoto T، Fujimoto S، Murakami T، Tsuda T (1998). "Expression of three calpain isoform genes in human skeletal muscles". J. Neurol. Sci. ج. 155 ع. 2: 163–9. DOI:10.1016/S0022-510X(97)00309-2. PMID:9562261.
Strobl S، Fernandez-Catalan C، Braun M، Huber R، Masumoto H، Nakagawa K، Irie A، Sorimachi H، Bourenkow G، Bartunik H، Suzuki K، Bode W (2000). "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 2: 588–92. DOI:10.1073/pnas.97.2.588. PMC:15374. PMID:10639123.
Masumoto H، Nakagawa K، Irie S، Sorimachi H، Suzuki K، Bourenkov GP، Bartunik H، Fernandez-Catalan C، Bode W، Strobl S (2000). "Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain". Acta Crystallogr. D. ج. 56 ع. Pt 1: 73–5. DOI:10.1107/S0907444999013748. PMID:10666632.
Chua BT، Guo K، Li P (2000). "Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases". J. Biol. Chem. ج. 275 ع. 7: 5131–5. DOI:10.1074/jbc.275.7.5131. PMID:10671558.
Lee MS، Kwon YT، Li M، Peng J، Friedlander RM، Tsai LH (2000). "Neurotoxicity induces cleavage of p35 to p25 by calpain". Nature. ج. 405 ع. 6784: 360–4. DOI:10.1038/35012636. PMID:10830966.

هذه بذرة مقالة عن جين على كروموسوم 1 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid2539381-1] Hata A، Ohno S، Akita Y، Suzuki K (مايو 1989). "Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease". J. Biol. Chem. ج. 264 ع. 11: 6404–11. PMID:2539381.

[pmid2852952-2] Imajoh S، Aoki K، Ohno S، Emori Y، Kawasaki H، Sugihara H، Suzuki K (1988). "Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease". Biochemistry. ج. 27 ع. 21: 8122–8. DOI:10.1021/bi00421a022. PMID:2852952.

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