ATF6

An Error has occured retrieving Wikidata item for infobox ATF6‏ (Activating transcription factor 6) هوَ بروتين يُشَفر بواسطة جين ATF6 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ Zhu C، Johansen FE، Prywes R (سبتمبر 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. ج. 17 ع. 9: 4957–66. PMC:232347. PMID:9271374. مؤرشف من الأصل في 2011-05-24.
^ Meex SJ، van Greevenbroek MM، Ayoubi TA، Vlietinck R، van Vliet-Ostaptchouk JV، Hofker MH، Vermeulen VM، Schalkwijk CG، Feskens EJ، Boer JM، Stehouwer CD، van der Kallen CJ، de Bruin TW (يوليو 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. ج. 92 ع. 7: 2720–5. DOI:10.1210/jc.2006-2280. PMID:17440018.
^ Hai TW، Liu F، Coukos WJ، Green MR (ديسمبر 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. ج. 3 ع. 12B: 2083–90. DOI:10.1101/gad.3.12b.2083. PMID:2516827.

قراءة متعمقة

Hai T، Hartman MG (2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene. ج. 273 ع. 1: 1–11. DOI:10.1016/S0378-1119(01)00551-0. PMID:11483355.
Hai TW، Liu F، Coukos WJ، Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. ج. 3 ع. 12B: 2083–90. DOI:10.1101/gad.3.12b.2083. PMID:2516827.
Zhu C، Johansen FE، Prywes R (1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. ج. 17 ع. 9: 4957–66. PMC:232347. PMID:9271374.
Yoshida H، Haze K، Yanagi H، Yura T، Mori K (1999). "Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors". J. Biol. Chem. ج. 273 ع. 50: 33741–9. DOI:10.1074/jbc.273.50.33741. PMID:9837962.
Haze K، Yoshida H، Yanagi H، Yura T، Mori K (1999). "Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress". Mol. Biol. Cell. ج. 10 ع. 11: 3787–99. DOI:10.1091/mbc.10.11.3787. PMC:25679. PMID:10564271.
Li M، Baumeister P، Roy B، Phan T، Foti D، Luo S، Lee AS (2000). "ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1". Mol. Cell. Biol. ج. 20 ع. 14: 5096–106. DOI:10.1128/MCB.20.14.5096-5106.2000. PMC:85959. PMID:10866666.
Yoshida H، Okada T، Haze K، Yanagi H، Yura T، Negishi M، Mori K (2001). "Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response". Mol. Cell. Biol. ج. 21 ع. 4: 1239–48. DOI:10.1128/MCB.21.4.1239-1248.2001. PMC:99577. PMID:11158310.
Ye J، Rawson RB، Komuro R، Chen X، Davé UP، Prywes R، Brown MS، Goldstein JL (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. ج. 6 ع. 6: 1355–64. DOI:10.1016/S1097-2765(00)00133-7. PMID:11163209.
Parker R، Phan T، Baumeister P، Roy B، Cheriyath V، Roy AL، Lee AS (2001). "Identification of TFII-I as the Endoplasmic Reticulum Stress Response Element Binding Factor ERSF: Its Autoregulation by Stress and Interaction with ATF6". Mol. Cell. Biol. ج. 21 ع. 9: 3220–33. DOI:10.1128/MCB.21.9.3220-3233.2001. PMC:86961. PMID:11287625.
Gotoh T، Oyadomari S، Mori K، Mori M (2002). "Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP". J. Biol. Chem. ج. 277 ع. 14: 12343–50. DOI:10.1074/jbc.M107988200. PMID:11805088.
Chen X، Shen J، Prywes R (2002). "The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi". J. Biol. Chem. ج. 277 ع. 15: 13045–52. DOI:10.1074/jbc.M110636200. PMID:11821395.
Thuerauf DJ، Morrison LE، Hoover H، Glembotski CC (2002). "Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16". J. Biol. Chem. ج. 277 ع. 23: 20734–9. DOI:10.1074/jbc.M201749200. PMID:11909875.
Okada T، Yoshida H، Akazawa R، Negishi M، Mori K (2002). "Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response". Biochem. J. ج. 366 ع. Pt 2: 585–94. DOI:10.1042/BJ20020391. PMC:1222788. PMID:12014989.
Luo S، Lee AS (2002). "Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation". Biochem. J. ج. 366 ع. Pt 3: 787–95. DOI:10.1042/BJ20011802. PMC:1222838. PMID:12076252.
Tardif KD، Mori K، Siddiqui A (2002). "Hepatitis C Virus Subgenomic Replicons Induce Endoplasmic Reticulum Stress Activating an Intracellular Signaling Pathway". J. Virol. ج. 76 ع. 15: 7453–9. DOI:10.1128/JVI.76.15.7453-7459.2002. PMC:136367. PMID:12097557.
Shuda M، Kondoh N، Imazeki N، Tanaka K، Okada T، Mori K، Hada A، Arai M، Wakatsuki T، Matsubara O، Yamamoto N، Yamamoto M (2004). "Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis". J. Hepatol. ج. 38 ع. 5: 605–14. DOI:10.1016/S0168-8278(03)00029-1. PMID:12713871.
Okada T، Haze K، Nadanaka S، Yoshida H، Seidah NG، Hirano Y، Sato R، Negishi M، Mori K (2003). "A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6". J. Biol. Chem. ج. 278 ع. 33: 31024–32. DOI:10.1074/jbc.M300923200. PMID:12782636.
Newman JR، Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. ج. 300 ع. 5628: 2097–101. DOI:10.1126/science.1084648. PMID:12805554.

هذه بذرة مقالة عن جين على كروموسوم 1 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid9271374-1] Zhu C، Johansen FE، Prywes R (سبتمبر 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. ج. 17 ع. 9: 4957–66. PMC:232347. PMID:9271374. مؤرشف من الأصل في 2011-05-24.

[pmid17440018-2] Meex SJ، van Greevenbroek MM، Ayoubi TA، Vlietinck R، van Vliet-Ostaptchouk JV، Hofker MH، Vermeulen VM، Schalkwijk CG، Feskens EJ، Boer JM، Stehouwer CD، van der Kallen CJ، de Bruin TW (يوليو 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. ج. 92 ع. 7: 2720–5. DOI:10.1210/jc.2006-2280. PMID:17440018.

[pmid2516827-3] Hai TW، Liu F، Coukos WJ، Green MR (ديسمبر 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. ج. 3 ع. 12B: 2083–90. DOI:10.1101/gad.3.12b.2083. PMID:2516827.

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