HEY1

An Error has occured retrieving Wikidata item for infobox HEY1‏ (Hes related family bHLH transcription factor with YRPW motif 1) هوَ بروتين يُشَفر بواسطة جين HEY1 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1". مؤرشف من الأصل في 2010-12-05.
^ Leimeister C، Externbrink A، Klamt B، Gessler M (يوليو 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. ج. 85 ع. 1–2: 173–7. DOI:10.1016/S0925-4773(99)00080-5. PMID:10415358.
^ Kokubo H، Lun Y، Johnson RL (يوليو 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. ج. 260 ع. 2: 459–65. DOI:10.1006/bbrc.1999.0880. PMID:10403790.

قراءة متعمقة

Iso T، Kedes L، Hamamori Y (مارس 2003). "HES and HERP families: multiple effectors of the Notch signaling pathway". Journal of Cellular Physiology. ج. 194 ع. 3: 237–55. DOI:10.1002/jcp.10208. PMID:12548545.
Kokubo H، Miyagawa-Tomita S، Johnson RL (يوليو 2005). "Hesr, a mediator of the Notch signaling, functions in heart and vessel development". Trends in Cardiovascular Medicine. ج. 15 ع. 5: 190–4. DOI:10.1016/j.tcm.2005.05.005. PMID:16165016.
Maruyama K، Sugano S (يناير 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. ج. 138 ع. 1–2: 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID:8125298.
Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، Suyama A، Sugano S (أكتوبر 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
Chin MT، Maemura K، Fukumoto S، Jain MK، Layne MD، Watanabe M، Hsieh CM، Lee ME (مارس 2000). "Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system". The Journal of Biological Chemistry. ج. 275 ع. 9: 6381–7. DOI:10.1074/jbc.275.9.6381. PMID:10692439.
Steidl C، Leimeister C، Klamt B، Maier M، Nanda I، Dixon M، Clarke R، Schmid M، Gessler M (يونيو 2000). "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family". Genomics. ج. 66 ع. 2: 195–203. DOI:10.1006/geno.2000.6200. PMID:10860664.
Maier MM، Gessler M (أغسطس 2000). "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes". Biochemical and Biophysical Research Communications. ج. 275 ع. 2: 652–60. DOI:10.1006/bbrc.2000.3354. PMID:10964718.
Nakagawa O، McFadden DG، Nakagawa M، Yanagisawa H، Hu T، Srivastava D، Olson EN (ديسمبر 2000). "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling". Proceedings of the National Academy of Sciences of the United States of America. ج. 97 ع. 25: 13655–60. DOI:10.1073/pnas.250485597. PMC:17631. PMID:11095750.
Sun J، Kamei CN، Layne MD، Jain MK، Liao JK، Lee ME، Chin MT (مايو 2001). "Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2". The Journal of Biological Chemistry. ج. 276 ع. 21: 18591–6. DOI:10.1074/jbc.M101163200. PMID:11279181.
Iso T، Sartorelli V، Chung G، Shichinohe T، Kedes L، Hamamori Y (سبتمبر 2001). "HERP, a new primary target of Notch regulated by ligand binding". Molecular and Cellular Biology. ج. 21 ع. 17: 6071–9. DOI:10.1128/MCB.21.17.6071-6079.2001. PMC:87324. PMID:11486044.
Taylor KL، Henderson AM، Hughes CC (نوفمبر 2002). "Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression". Microvascular Research. ج. 64 ع. 3: 372–83. DOI:10.1006/mvre.2002.2443. PMID:12453432.
Elagib KE، Xiao M، Hussaini IM، Delehanty LL، Palmer LA، Racke FK، Birrer MJ، Ganapathy-Kanniappan S، Shanmugasundaram G، McDevitt MA، Goldfarb AN (سبتمبر 2004). "Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2". Molecular and Cellular Biology. ج. 24 ع. 17: 7779–94. DOI:10.1128/MCB.24.17.7779-7794.2004. PMC:506977. PMID:15314183.
Suzuki Y، Yamashita R، Shirota M، Sakakibara Y، Chiba J، Mizushima-Sugano J، Nakai K، Sugano S (سبتمبر 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. ج. 14 ع. 9: 1711–8. DOI:10.1101/gr.2435604. PMC:515316. PMID:15342556.
Kokubo H، Miyagawa-Tomita S، Nakazawa M، Saga Y، Johnson RL (فبراير 2005). "Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system". Developmental Biology. ج. 278 ع. 2: 301–9. DOI:10.1016/j.ydbio.2004.10.025. PMID:15680351.

هذه بذرة مقالة عن جين على كروموسوم 8 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1". مؤرشف من الأصل في 2010-12-05.

[pmid10415358-2] Leimeister C، Externbrink A، Klamt B، Gessler M (يوليو 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. ج. 85 ع. 1–2: 173–7. DOI:10.1016/S0925-4773(99)00080-5. PMID:10415358.

[pmid10403790-3] Kokubo H، Lun Y، Johnson RL (يوليو 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. ج. 260 ع. 2: 459–65. DOI:10.1006/bbrc.1999.0880. PMID:10403790.

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