RASSF2

An Error has occured retrieving Wikidata item for infobox RASSF2‏ (Ras association domain family member 2) هوَ بروتين يُشَفر بواسطة جين RASSF2 في الإنسان.^[1]^[2]^[3]^[1]

الوظيفة

الأهمية السريرية

المراجع

^ ^أ ^ب "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2". مؤرشف من الأصل في 2010-12-05.
^ Nagase T، Seki N، Ishikawa K، Tanaka A، Nomura N (نوفمبر 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. ج. 3 ع. 1: 17–24. DOI:10.1093/dnares/3.1.17. PMID:8724849.
^ Hesson LB، Wilson R، Morton D، Adams C، Walker M، Maher ER، Latif F (يونيو 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. ج. 24 ع. 24: 3987–94. DOI:10.1038/sj.onc.1208566. PMID:15806169.

قراءة متعمقة

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Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، وآخرون (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
Comincini S، Castiglioni BM، Foti GM، وآخرون (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene". Mamm. Genome. ج. 12 ع. 2: 150–6. DOI:10.1007/s003350010239. PMID:11210185.
Deloukas P، Matthews LH، Ashurst J، وآخرون (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. ج. 414 ع. 6866: 865–71. Bibcode:2001Natur.414..865D. DOI:10.1038/414865a. PMID:11780052.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Vos MD، Ellis CA، Elam C، وآخرون (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. ج. 278 ع. 30: 28045–51. DOI:10.1074/jbc.M300554200. PMID:12732644.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Fujita H، Fukuhara S، Sakurai A، وآخرون (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. ج. 280 ع. 6: 5022–31. DOI:10.1074/jbc.M409701200. PMID:15569673.
Akino K، Toyota M، Suzuki H، وآخرون (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. ج. 129 ع. 1: 156–69. DOI:10.1053/j.gastro.2005.03.051. PMID:16012945.
Endoh M، Tamura G، Honda T، وآخرون (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer". Br. J. Cancer. ج. 93 ع. 12: 1395–9. DOI:10.1038/sj.bjc.6602854. PMC:2361541. PMID:16265349.
Zhang Z، Sun D، Van do N، وآخرون (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma". Int. J. Cancer. ج. 120 ع. 1: 32–8. DOI:10.1002/ijc.22185. PMID:17013896.
Park HW، Kang HC، Kim IJ، وآخرون (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers". Int. J. Cancer. ج. 120 ع. 1: 7–12. DOI:10.1002/ijc.22276. PMID:17013898.
Kumari G، Singhal PK، Rao MR، Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals". J. Mol. Biol. ج. 367 ع. 5: 1294–311. DOI:10.1016/j.jmb.2007.01.026. PMID:17320110.
Kaira K، Sunaga N، Tomizawa Y، وآخرون (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers". Int. J. Oncol. ج. 31 ع. 1: 169–73. DOI:10.3892/ijo.31.1.169. PMID:17549418.

هذه بذرة مقالة عن جين على كروموسوم 20 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] أ ^ب "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2". مؤرشف من الأصل في 2010-12-05.

[pmid8724849-2] Nagase T، Seki N، Ishikawa K، Tanaka A، Nomura N (نوفمبر 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. ج. 3 ع. 1: 17–24. DOI:10.1093/dnares/3.1.17. PMID:8724849.

[pmid15806169-3] Hesson LB، Wilson R، Morton D، Adams C، Walker M، Maher ER، Latif F (يونيو 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. ج. 24 ع. 24: 3987–94. DOI:10.1038/sj.onc.1208566. PMID:15806169.

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