SLIT2

An Error has occured retrieving Wikidata item for infobox SLIT2‏ (Slit guidance ligand 2) هوَ بروتين يُشَفر بواسطة جين SLIT2 في الإنسان.^[1]^[2]^[3]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: SLIT2 slit homolog 2 (Drosophila)". مؤرشف من الأصل في 2010-12-05.
^ Itoh A؛ Miyabayashi T؛ Ohno M؛ Sakano S (فبراير 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res. ج. 62 ع. 2: 175–86. DOI:10.1016/S0169-328X(98)00224-1. PMID:9813312.
^ Chedotal A (فبراير 2008). "Slits and their receptors". Adv Exp Med Biol. ج. 621: 65–80. DOI:10.1007/978-0-387-76715-4_5. PMID:18269211.

قراءة متعمقة

Wong K؛ Park HT؛ Wu JY؛ Rao Y (2003). "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes". Curr. Opin. Genet. Dev. ج. 12 ع. 5: 583–91. DOI:10.1016/S0959-437X(02)00343-X. PMID:12200164.
Zhao XC؛ Zhang LM؛ Li Q؛ Tong DY؛ Fan LC؛ An P؛ Wu XY؛ Chen WM؛ Zhao P؛ Wang J. (2013). "Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1". Brain Res. ج. 1537: 283–9. DOI:10.1016/j.brainres.2013.08.036. PMC:3820100. PMID:23994690.
Wang KH، Brose K، Arnott D، وآخرون (1999). "Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching". Cell. ج. 96 ع. 6: 771–84. DOI:10.1016/S0092-8674(00)80588-7. PMID:10102266.
Brose K، Bland KS، Wang KH، وآخرون (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. ج. 96 ع. 6: 795–806. DOI:10.1016/S0092-8674(00)80590-5. PMID:10102268.
Li HS، Chen JH، Wu W، وآخرون (1999). "Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons". Cell. ج. 96 ع. 6: 807–18. DOI:10.1016/S0092-8674(00)80591-7. PMID:10102269.
Nguyen Ba-Charvet KT، Brose K، Marillat V، وآخرون (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. ج. 22 ع. 3: 463–73. DOI:10.1016/S0896-6273(00)80702-3. PMID:10197527.
Holmes GP، Negus K، Burridge L، وآخرون (1999). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis". Mech. Dev. ج. 79 ع. 1–2: 57–72. DOI:10.1016/S0925-4773(98)00174-9. PMID:10349621.
Liang Y، Annan RS، Carr SA، وآخرون (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. ج. 274 ع. 25: 17885–92. DOI:10.1074/jbc.274.25.17885. PMID:10364234.
Wu W، Wong K، Chen J، وآخرون (1999). "Directional guidance of neuronal migration in the olfactory system by the protein Slit". Nature. ج. 400 ع. 6742: 331–6. Bibcode:1999Natur.400..331W. DOI:10.1038/22477. PMC:2041931. PMID:10432110.
Georgas K، Burridge L، Smith K، وآخرون (2000). "Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2". Cytogenet. Cell Genet. ج. 86 ع. 3–4: 246–7. DOI:10.1159/000015351. PMID:10575218.
Niclou SP؛ Jia L؛ Raper JA (2000). "Slit2 is a repellent for retinal ganglion cell axons". J. Neurosci. ج. 20 ع. 13: 4962–74. PMID:10864954.
Zou Y؛ Stoeckli E؛ Chen H؛ Tessier-Lavigne M (2000). "Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord". Cell. ج. 102 ع. 3: 363–75. DOI:10.1016/S0092-8674(00)00041-6. PMID:10975526.
Chen JH، Wen L، Dupuis S، وآخرون (2001). "The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons". J. Neurosci. ج. 21 ع. 5: 1548–56. PMID:11222645.
Stein E؛ Tessier-Lavigne M (2001). "Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex". Science. ج. 291 ع. 5510: 1928–38. Bibcode:2001Sci...291.1928S. DOI:10.1126/science.1058445. PMID:11239147.
Wu JY، Feng L، Park HT، وآخرون (2001). "The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors". Nature. ج. 410 ع. 6831: 948–52. DOI:10.1038/35073616. PMC:2072862. PMID:11309622.
Ronca F؛ Andersen JS؛ Paech V؛ Margolis RU (2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. ج. 276 ع. 31: 29141–7. DOI:10.1074/jbc.M100240200. PMID:11375980.
Nguyen Ba-Charvet KT، Brose K، Ma L، وآخرون (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". J. Neurosci. ج. 21 ع. 12: 4281–9. PMID:11404413.
Little M، Rumballe B، Georgas K، وآخرون (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". Int. J. Dev. Biol. ج. 46 ع. 4: 385–91. PMID:12141424.
Dallol A، Da Silva NF، Viacava P، وآخرون (2002). "SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers". Cancer Res. ج. 62 ع. 20: 5874–80. PMID:12384551.

هذه بذرة مقالة عن جين على كروموسوم 4 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: SLIT2 slit homolog 2 (Drosophila)". مؤرشف من الأصل في 2010-12-05.

[pmid9813312-2] Itoh A؛ Miyabayashi T؛ Ohno M؛ Sakano S (فبراير 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res. ج. 62 ع. 2: 175–86. DOI:10.1016/S0169-328X(98)00224-1. PMID:9813312.

[pmid18269211-3] Chedotal A (فبراير 2008). "Slits and their receptors". Adv Exp Med Biol. ج. 621: 65–80. DOI:10.1007/978-0-387-76715-4_5. PMID:18269211.

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