APBA2

An Error has occured retrieving Wikidata item for infobox APBA2‏ (Amyloid beta precursor protein binding family A member 2) هوَ بروتين يُشَفر بواسطة جين APBA2 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ McLoughlin DM، Miller CC (يناير 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. ج. 397 ع. 2–3: 197–200. DOI:10.1016/S0014-5793(96)01128-3. PMID:8955346.
^ "Entrez Gene: APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)". مؤرشف من الأصل في 2010-12-05.

قراءة متعمقة

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Yu W، Andersson B، Worley KC، Muzny DM، Ding Y، Liu W، Ricafrente JY، Wentland MA، Lennon G، Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. ج. 7 ع. 4: 353–8. DOI:10.1101/gr.7.4.353. PMC:139146. PMID:9110174.
Okamoto M، Südhof TC (1998). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis". J. Biol. Chem. ج. 272 ع. 50: 31459–64. DOI:10.1074/jbc.272.50.31459. PMID:9395480.
Blanco G، Irving NG، Brown SD، Miller CC، McLoughlin DM (1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm. Genome. ج. 9 ع. 6: 473–5. DOI:10.1007/s003359900800. PMID:9585438.
Borg JP، Yang Y، De Taddéo-Borg M، Margolis B، Turner RS (1998). "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion". J. Biol. Chem. ج. 273 ع. 24: 14761–6. DOI:10.1074/jbc.273.24.14761. PMID:9614075.
Borg JP، Straight SW، Kaech SM، de Taddéo-Borg M، Kroon DE، Karnak D، Turner RS، Kim SK، Margolis B (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. ج. 273 ع. 48: 31633–6. DOI:10.1074/jbc.273.48.31633. PMID:9822620.
Okamoto M، Südhof TC (1999). "Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2". Eur. J. Cell Biol. ج. 77 ع. 3: 161–5. DOI:10.1016/s0171-9335(98)80103-9. PMID:9860131.
Tomita S، Ozaki T، Taru H، Oguchi S، Takeda S، Yagi Y، Sakiyama S، Kirino Y، Suzuki T (1999). "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein". J. Biol. Chem. ج. 274 ع. 4: 2243–54. DOI:10.1074/jbc.274.4.2243. PMID:9890987.
McLoughlin DM، Irving NG، Brownlees J، Brion JP، Leroy K، Miller CC (1999). "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease". Eur. J. Neurosci. ج. 11 ع. 6: 1988–94. DOI:10.1046/j.1460-9568.1999.00610.x. PMID:10336668.
Tomita S، Fujita T، Kirino Y، Suzuki T (2000). "PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein". J. Biol. Chem. ج. 275 ع. 17: 13056–60. DOI:10.1074/jbc.C000019200. PMID:10777610.
Gotthardt M، Trommsdorff M، Nevitt MF، Shelton J، Richardson JA، Stockinger W، Nimpf J، Herz J (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. ج. 275 ع. 33: 25616–24. DOI:10.1074/jbc.M000955200. PMID:10827173.
Lee DS، Tomita S، Kirino Y، Suzuki T (2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J. Biol. Chem. ج. 275 ع. 30: 23134–8. DOI:10.1074/jbc.C000302200. PMID:10833507.
Biederer T، Südhof TC (2001). "Mints as adaptors. Direct binding to neurexins and recruitment of munc18". J. Biol. Chem. ج. 275 ع. 51: 39803–6. DOI:10.1074/jbc.C000656200. PMID:11036064.
Lau KF، McLoughlin DM، Standen C، Miller CC (2001). "X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains". Mol. Cell. Neurosci. ج. 16 ع. 5: 557–65. DOI:10.1006/mcne.2000.0898. PMID:11083918.
Sutcliffe JS، Han MK، Amin T، Kesterson RA، Nurmi EL (2003). "Partial duplication of the APBA2 gene in chromosome 15q13 corresponds to duplicon structures". BMC Genomics. ج. 4: 15. DOI:10.1186/1471-2164-4-15. PMC:156605. PMID:12720574.
Sumioka A، Imoto S، Martins RN، Kirino Y، Suzuki T (2003). "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms". Biochem. J. ج. 374 ع. Pt 1: 261–8. DOI:10.1042/BJ20030489. PMC:1223589. PMID:12780348.

APBA2 في المشاريع الشقيقة:

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[pmid8955346-1] McLoughlin DM، Miller CC (يناير 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. ج. 397 ع. 2–3: 197–200. DOI:10.1016/S0014-5793(96)01128-3. PMID:8955346.

[entrez-2] "Entrez Gene: APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)". مؤرشف من الأصل في 2010-12-05.

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