WIF1

An Error has occured retrieving Wikidata item for infobox WIF1‏ (Wnt inhibitory factor 1) هوَ بروتين يُشَفر بواسطة جين WIF1 في الإنسان.^[1]^[2]^[3]^[4]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: WIF1 WNT inhibitory factor 1". مؤرشف من الأصل في 2010-12-05.
^ Hsieh JC، Kodjabachian L، Rebbert ML، Rattner A، Smallwood PM، Samos CH، Nusse R، Dawid IB، Nathans J (أبريل 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. ج. 398 ع. 6726: 431–6. DOI:10.1038/18899. PMID:10201374.
^ Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. ج. 43 ع. 3: 227–30. DOI:10.1007/s11745-007-3144-3. PMID:18256869.
^ Malinauskas T، Aricescu AR، Lu W، Siebold C، Jones EY (يوليو 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. ج. 18 ع. 8: 886–893. DOI:10.1038/nsmb.2081. PMC:3430870. PMID:21743455.

قراءة متعمقة

Shepelev MV، Korobko EV، Korobko IV (2006). "[WIF1: perspectives of application in oncology]". Mol. Gen. Mikrobiol. Virusol. ع. 4: 3–7. PMID:17094650.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Clark HF، Gurney AL، Abaya E، وآخرون (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. ج. 13 ع. 10: 2265–70. DOI:10.1101/gr.1293003. PMC:403697. PMID:12975309.
Reguart N، He B، Xu Z، وآخرون (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1". Biochem. Biophys. Res. Commun. ج. 323 ع. 1: 229–34. DOI:10.1016/j.bbrc.2004.08.075. PMID:15351726.
Esufali S، Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation". Oncogene. ج. 23 ع. 50: 8260–71. DOI:10.1038/sj.onc.1208007. PMID:15377999.
Ohigashi T، Mizuno R، Nakashima J، وآخرون (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells". Prostate. ج. 62 ع. 1: 61–8. DOI:10.1002/pros.20117. PMID:15389810.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Simon M، Grandage VL، Linch DC، Khwaja A (2005). "Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia". Oncogene. ج. 24 ع. 14: 2410–20. DOI:10.1038/sj.onc.1208431. PMID:15735743.
Taniguchi H، Yamamoto H، Hirata T، وآخرون (2005). "Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers". Oncogene. ج. 24 ع. 53: 7946–52. DOI:10.1038/sj.onc.1208910. PMID:16007117.
Lin YC، You L، Xu Z، وآخرون (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines". Biochem. Biophys. Res. Commun. ج. 341 ع. 2: 635–40. DOI:10.1016/j.bbrc.2005.12.220. PMID:16427602.
Urakami S، Shiina H، Enokida H، وآخرون (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway". Clin. Cancer Res. ج. 12 ع. 2: 383–91. DOI:10.1158/1078-0432.CCR-05-1344. PMID:16428476.
Liepinsh E، Bányai L، Patthy L، Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1". J. Mol. Biol. ج. 357 ع. 3: 942–50. DOI:10.1016/j.jmb.2006.01.047. PMID:16476441.
Batra S، Shi Y، Kuchenbecker KM، وآخرون (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma". Biochem. Biophys. Res. Commun. ج. 342 ع. 4: 1228–32. DOI:10.1016/j.bbrc.2006.02.084. PMID:16516163.
Chim CS، Chan WW، Pang A، Kwong YL (2006). "Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor". Leukemia. ج. 20 ع. 5: 907–9. DOI:10.1038/sj.leu.2404176. PMID:16525492.
Urakami S، Shiina H، Enokida H، وآخرون (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection". Clin. Cancer Res. ج. 12 ع. 7 Pt 1: 2109–16. DOI:10.1158/1078-0432.CCR-05-2468. PMID:16609023.
Milutinovic S، D'Alessio AC، Detich N، Szyf M (2007). "Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes". Carcinogenesis. ج. 28 ع. 3: 560–71. DOI:10.1093/carcin/bgl167. PMID:17012225.
Queimado L، Lopes CS، Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors". Genes Chromosomes Cancer. ج. 46 ع. 3: 215–25. DOI:10.1002/gcc.20402. PMID:17171686.
Chan SL، Cui Y، van Hasselt A، وآخرون (2007). "The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas". Lab. Invest. ج. 87 ع. 7: 644–50. DOI:10.1038/labinvest.3700547. PMID:17384664.
Veeck J، Wild PJ، Fuchs T، وآخرون (2009). "Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer". BMC Cancer. ج. 9: 1–13. DOI:10.1186/1471-2407-9-217. PMC:2717119. PMID:19570204.

هذه بذرة مقالة عن بروتين بحاجة للتوسيع. فضلًا شارك في تحريرها.

[entrez-1] "Entrez Gene: WIF1 WNT inhibitory factor 1". مؤرشف من الأصل في 2010-12-05.

[pmid10201374-2] Hsieh JC، Kodjabachian L، Rebbert ML، Rattner A، Smallwood PM، Samos CH، Nusse R، Dawid IB، Nathans J (أبريل 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. ج. 398 ع. 6726: 431–6. DOI:10.1038/18899. PMID:10201374.

[pmid=18256869-3] Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. ج. 43 ع. 3: 227–30. DOI:10.1007/s11745-007-3144-3. PMID:18256869.

[pmid21743455-4] Malinauskas T، Aricescu AR، Lu W، Siebold C، Jones EY (يوليو 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. ج. 18 ع. 8: 886–893. DOI:10.1038/nsmb.2081. PMC:3430870. PMID:21743455.

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