STATH

An Error has occured retrieving Wikidata item for infobox STATH‏ (Statherin) هوَ بروتين يُشَفر بواسطة جين STATH في الإنسان.^[1]^[2]^[3]

الوظيفة

يمنع ترسيب فوسفات الكالسيوم في اللعاب، للحفاظ على مستوى عالي من الكالسيوم في اللعاب لإتاحة إعادة تمعدن مينا الأسنان، ومستويات فوسفات عالية من أجل التنظيم.^[3]

الأهمية السريرية

المراجع

^ Sabatini LM، Carlock LR، Johnson GW، Azen EA (يناير 1988). "cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva". Am J Hum Genet. ج. 41 ع. 6: 1048–60. PMC:1684366. PMID:3502720.
^ "Entrez Gene: STATH statherin". مؤرشف من الأصل في 2010-12-05.
^ ^أ ^ب Hay DI، Smith DJ، Schluckebier SK، Moreno EC (1984). "Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva". J. Dent. Res. ج. 63 ع. 6: 857–63. DOI:10.1177/00220345840630060901. PMID:6429216.

قراءة متعمقة

Schlesinger DH، Hay DI (1977). "Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva". J. Biol. Chem. ج. 252 ع. 5: 1689–95. PMID:838735.
Raj PA، Johnsson M، Levine MJ، Nancollas GH (1992). "Salivary statherin. Dependence on sequence, charge, hydrogen bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization". J. Biol. Chem. ج. 267 ع. 9: 5968–76. PMID:1313424.
Douglas WH، Reeh ES، Ramasubbu N، Raj PA، Bhandary KK، Levine MJ (1991). "Statherin: a major boundary lubricant of human saliva". Biochem. Biophys. Res. Commun. ج. 180 ع. 1: 91–7. DOI:10.1016/S0006-291X(05)81259-8. PMID:1718282.
Johnsson M، Richardson CF، Bergey EJ، Levine MJ، Nancollas GH (1992). "The effects of human salivary cystatins and statherin on hydroxyapatite crystallization". Arch. Oral Biol. ج. 36 ع. 9: 631–6. DOI:10.1016/0003-9969(91)90014-L. PMID:1741693.
Ramasubbu N، Reddy MS، Bergey EJ، Haraszthy GG، Soni SD، Levine MJ (1992). "Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva". Biochem. J. 280 ( Pt 2) ع. Pt 2: 341–52. PMC:1130552. PMID:1747107.
Sabatini LM، He YZ، Azen EA (1990). "Structure and sequence determination of the gene encoding human salivary statherin". Gene. ج. 89 ع. 2: 245–51. DOI:10.1016/0378-1119(90)90012-G. PMID:2373369.
Sabatini LM، Warner TF، Saitoh E، Azen EA (1990). "Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques". J. Dent. Res. ج. 68 ع. 7: 1138–45. DOI:10.1177/00220345890680070101. PMID:2483725.
Dickinson DP، Ridall AL، Levine MJ (1988). "Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence". Biochem. Biophys. Res. Commun. ج. 149 ع. 2: 784–90. DOI:10.1016/0006-291X(87)90436-0. PMID:3426601.
Oppenheim FG، Hay DI، Smith DJ، Offner GD، Troxler RF (1987). "Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides". J. Dent. Res. ج. 66 ع. 2: 462–6. DOI:10.1177/00220345870660021301. PMID:3476566.
Perinpanayagam HE، Van Wuyckhuyse BC، Ji ZS، Tabak LA (1995). "Characterization of low-molecular-weight peptides in human parotid saliva". J. Dent. Res. ج. 74 ع. 1: 345–50. DOI:10.1177/00220345950740011001. PMID:7876428.
Gururaja TL، Levine MJ (1997). "Solid-phase synthesis and characterization of human salivary statherin: a tyrosine-rich phosphoprotein inhibitor of calcium phosphate precipitation". Pept. Res. ج. 9 ع. 6: 283–9. PMID:9048421.
Iontcheva I، Oppenheim FG، Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. ج. 76 ع. 3: 734–43. DOI:10.1177/00220345970760030501. PMID:9109822.
Iontcheva I، Oppenheim FG، Offner GD، Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. ج. 79 ع. 2: 732–9. DOI:10.1177/00220345000790020601. PMID:10728974.
Gilbert M، Shaw WJ، Long JR، Nelson K، Drobny GP، Giachelli CM، Stayton PS (2000). "Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion". J. Biol. Chem. ج. 275 ع. 21: 16213–8. DOI:10.1074/jbc.M001773200. PMID:10748043.
Yao Y، Lamkin MS، Oppenheim FG (2000). "Pellicle precursor protein crosslinking characterization of an adduct between acidic proline-rich protein (PRP-1) and statherin generated by transglutaminase". J. Dent. Res. ج. 79 ع. 4: 930–8. DOI:10.1177/00220345000790040801. PMID:10831095.
Tamaki N، Tada T، Morita M، Watanabe T (2003). "Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1". Calcif. Tissue Int. ج. 71 ع. 1: 59–62. DOI:10.1007/s00223-001-1084-0. PMID:12060866.
Yao Y، Berg EA، Costello CE، Troxler RF، Oppenheim FG (2003). "Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches". J. Biol. Chem. ج. 278 ع. 7: 5300–8. DOI:10.1074/jbc.M206333200. PMID:12444093.

هذه بذرة مقالة عن جين على كروموسوم 4 بحاجة للتوسيع. فضلًا شارك في تحريرها.

[pmid3502720-1] Sabatini LM، Carlock LR، Johnson GW، Azen EA (يناير 1988). "cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva". Am J Hum Genet. ج. 41 ع. 6: 1048–60. PMC:1684366. PMID:3502720.

[entrez-2] "Entrez Gene: STATH statherin". مؤرشف من الأصل في 2010-12-05.

[pmid6429216-3] أ ^ب Hay DI، Smith DJ، Schluckebier SK، Moreno EC (1984). "Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva". J. Dent. Res. ج. 63 ع. 6: 857–63. DOI:10.1177/00220345840630060901. PMID:6429216.

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