English: The letters of MISSISSIPPI can be rearranged in 34650 different ways. Here we use the Rule of product applied to the binomial theorem, beginning with 11-choose-4 to count the possible locations of the four Is. Note that for the three Ss we used the fact that 0!=1. A version less biased towards the English language "spells" acetic acid (CHHHCOOH) at file:Multinomial theorem CH3COOH.svg