English: The human genes MT-ATP8 and MT-ATP6 located in the mitochondrial DNA and coding for the ATP synthase F0 subunits 8 and 6 overlap on 46 nucleotides.

The DNA sequence of this region of the human mitochondrial genome is given in black (positions 8,525 to 8,580 in the sequence accession NC_012920). There are three possible reading frames in the 5' -> 3' forward direction, starting on the first (+1), second (+2) and third position (+3). For each nucleotide triplet (square brackets), the corresponding amino acid is given (one-letter code), either in the +1 frame for MT-ATP8 (in red) or in the +3 frame for MT-ATP6 (in blue). The MT-ATP8 genes terminates with the TAG stop codon (red dot) in the +1 frame. The MT-ATP6 gene starts with the ATG codon (blue circle for the M amino acid) in the +3 frame.

Forteen sense codons do overlap for the two genes. As both genes use different ORF, the two protein sequences are different in the overlap region.