قالب:PBB/7124

Tumor necrosis factor
ملف:TNFa Crystal Structure.rsh.png بنك بيانات البروتينات rendering based on 1TNF.
التراكيب المتوفرة بنك بيانات البروتين بحث أورثولوغ: PDBe, RCSB قائمة رموز معرفات بنك بيانات البروتين 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
المعرفات
الرمز، (أو الرموز)	TNF; DIF; TNF-alpha; TNFA; TNFSF2
معرفات خارجية	OMIM: 191160 MGI: 104798 هومولوجين: 496 مختبر علم الأحياء الجزيئي الأوروبي الكيميائي: 1825 بطاقات الجينات: TNF Gene
علم الوجود الجيني الوظيفة الجزيئية • protease binding • cytokine activity • tumor necrosis factor receptor binding • protein binding • identical protein binding • transcription regulatory region DNA binding المكونات الخلوية • phagocytic cup • extracellular region • extracellular space • plasma membrane • integral component of plasma membrane • external side of plasma membrane • cell surface • membrane raft • recycling endosome العملية الإحيائية • protein import into nucleus, translocation • negative regulation of transcription from RNA polymerase II promoter • MAPK cascade • activation of MAPKKK activity • activation of MAPK activity • positive regulation of cytokine production • positive regulation of protein phosphorylation • chronic inflammatory response to antigenic stimulus • negative regulation of cytokine secretion involved in immune response • positive regulation of chronic inflammatory response to antigenic stimulus • positive regulation of humoral immune response mediated by circulating immunoglobulin • glucose metabolic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • transformed cell apoptotic process • inflammatory response • humoral immune response • cell surface receptor signaling pathway • JNK cascade • extrinsic apoptotic signaling pathway via death domain receptors • intrinsic apoptotic signaling pathway in response to DNA damage • response to virus • response to salt stress • positive regulation of gene expression • negative regulation of gene expression • negative regulation of alkaline phosphatase activity • negative regulation of lipid storage • extracellular matrix organization • osteoclast differentiation • sequestering of triglyceride • positive regulation of protein complex assembly • positive regulation of fever generation • lipopolysaccharide-mediated signaling pathway • negative regulation of interleukin-6 production • positive regulation of chemokine production • positive regulation of interferon-gamma production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • receptor biosynthetic process • positive regulation of peptidyl-serine phosphorylation • tumor necrosis factor-mediated signaling pathway • positive regulation of heterotypic cell-cell adhesion • positive regulation of NF-kappaB import into nucleus • positive regulation of apoptotic process • positive regulation of programmed cell death • regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of protein complex disassembly • positive regulation of protein complex disassembly • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of MAP kinase activity • protein kinase B signaling • positive regulation of JUN kinase activity • negative regulation of growth of symbiont in host • negative regulation of viral genome replication • positive regulation of chemokine biosynthetic process • positive regulation of interleukin-8 biosynthetic process • positive regulation of nitric oxide biosynthetic process • negative regulation of fat cell differentiation • negative regulation of myoblast differentiation • negative regulation of osteoblast differentiation • positive regulation of osteoclast differentiation • positive regulation of cell adhesion • positive regulation of protein kinase activity • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of translational initiation by iron • negative regulation of glucose import • embryonic digestive tract development • positive regulation of smooth muscle cell proliferation • positive regulation of cytokine secretion • positive regulation of phagocytosis • regulation of insulin secretion • defense response to Gram-positive bacterium • leukocyte tethering or rolling • negative regulation of lipid catabolic process • regulation of immunoglobulin secretion • positive regulation of membrane protein ectodomain proteolysis • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • positive regulation of protein transport • response to glucocorticoid • positive regulation of NFAT protein import into nucleus • positive regulation of hair follicle development • positive regulation of protein kinase B signaling • positive regulation of vitamin D biosynthetic process • positive regulation of calcidiol 1-monooxygenase activity • epithelial cell proliferation involved in salivary gland morphogenesis • regulation of branching involved in salivary gland morphogenesis • negative regulation of branching involved in lung morphogenesis • positive regulation of ERK1 and ERK2 cascade • cellular response to amino acid stimulus • cellular response to nicotine • cellular response to organic cyclic compound • death-inducing signaling complex assembly • positive regulation of mononuclear cell migration • positive regulation of podosome assembly • extrinsic apoptotic signaling pathway • necroptotic signaling pathway • positive regulation of protein localization to cell surface • positive regulation of chemokine (C-X-C motif) ligand 2 production • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand المصادر: Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
ملف:PBB GE TNF 207113 s at.png
مصادر أخرى عن بيانات أنماط التعبير
التقويمات
الأنواع	الإنسان	الفأر
أنتريه	7124	21926
انسمبل	ENSG00000204490	ENSMUSG00000024401
يونيبروت	P01375	P06804
قاعدة بيانات مرجعية (مرسال ر.ن.ا)	NM_000594	NM_001278601
قاعدة بيانات مرجعية (بروتين)	NP_000585	NP_001265530
الموقع (قاعدة بيانات UCSC)	Chr 6: 31.58 – 31.58 Mb	Chr 17: 35.2 – 35.2 Mb
بحث ببمد	[1]	[2]