عرض مصدر بوسنتان

{{صندوق معلومات دواء
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 459981656
| image = Bosentan.svg

<!-- Clinical data -->
| tradename = Tracleer, Stayveer
| Drugs.com = {{drugs.com|monograph|bosentan}}
| MedlinePlus = a605001
| licence_EU = yes
| DailyMedID = Bosentan
| pregnancy_AU      = X
| pregnancy_AU_comment = 
| pregnancy_US      = X
| pregnancy_US_comment = 
| pregnancy_category = X
| routes_of_administration = [[إعطاء فموي]]
| class             = 
| ATCvet            = 
| ATC_prefix = C02
| ATC_suffix = KX01
| ATC_supplemental  =

<!-- Legal status -->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment = 
| legal_BR =  <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment = 
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment = 
| legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment = 
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment = 
| legal_UK = POM
| legal_UK_comment = <ref name=UKlabel2017 />
| legal_US = Rx-only
| legal_US_comment = <ref name="Tracleer FDA label" />
| legal_EU = Rx-only
| legal_EU_comment = <ref name="Tracleer EPAR">{{استشهاد ويب | عنوان=Tracleer EPAR | موقع=[[وكالة الأدوية الأوروبية]] (EMA) | مسار=https://www.ema.europa.eu/en/medicines/human/EPAR/tracleer | تاريخ الوصول=16 October 2020| مسار أرشيف = https://web.archive.org/web/20211105175303/https://www.ema.europa.eu/en/medicines/human/EPAR/tracleer | تاريخ أرشيف = 5 نوفمبر 2021 }}</ref>
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment = 
| legal_status      = Rx-only

<!-- Pharmacokinetic data -->
| bioavailability = 50%
| protein_bound = >98%
| metabolism = [[كبد]]
| elimination_half-life = 5 hours

<!-- Identifiers -->
| index2_label = as monohydrate
| IUPHAR_ligand = 3494
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 147536-97-8
| PubChem = 104865
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00559
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 94651
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = XUL93R30K2
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = D07538
| KEGG2_Ref = {{keggcite|changed|kegg}}
| KEGG2 = D01227
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 51450
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 957

<!-- Chemical and physical data -->
| IUPAC_name = 4-''tert''-butyl-''N''-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide
| C=27 | H=29 | N=5 | O=6 | S=1
| SMILES = CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2c(c(nc(n2)c3ncccn3)OCCO)Oc4ccccc4OC
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GJPICJJJRGTNOD-UHFFFAOYSA-N
| density           = 
| density_notes     = 
| melting_point     = 
| melting_high      = 
| melting_notes     = 
| boiling_point     = 
| boiling_notes     = 
| solubility        = 
| sol_units         = 
| specific_rotation = 
}}

'''بوسنتان''' وهو دواء [[مضادات مستقبلات الإندوثيلين]] يستخدم في علاج ارتفاع [[فرط ضغط الدم الرئوي|ضغط الدم في الشريان الرئوي]] (PAH). ويُباع بوسنتان تحت الاسم التجاري (تراكلير:Tracleer).<ref name="Tracleer FDA label" /><ref name="Tracleer EPAR" />

ويتوفر بوسنتان كأقراص مغلفة (62.5 مجم أو 125 مجم) أو كأقراص قابلة للتشتت عن طريق الفم (32 مجم).<ref name="Tracleer FDA label">{{استشهاد ويب | عنوان=Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble | موقع=DailyMed | تاريخ=15 June 2020 | مسار=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=749e42fb-2fe0-45dd-9268-b43bb3f4081c | تاريخ الوصول=15 October 2020| مسار أرشيف = https://web.archive.org/web/20210512052048/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=749e42fb-2fe0-45dd-9268-b43bb3f4081c | تاريخ أرشيف = 12 مايو 2021 }}</ref>