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قالب:PBB/354 - تاريخ المراجعة
2026-06-06T08:44:05Z
تاريخ التعديل لهذه الصفحة في الويكي
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عبد العزيز: بوت: إصلاح التحويلات
2022-02-17T10:46:50Z
<p>بوت: إصلاح التحويلات</p>
<p><b>صفحة جديدة</b></p><div>{{GNF_Protein_box<br />
| Name = Kallikrein-related peptidase 3<br />
| image = PSA_KLK3_PDB_2ZCK.png<br />
| image_source = [[دراسة البلورات بالأشعة السينية#Biological_macromolecular_crystallography|Crystallographic structure]] of human prostate-specific antigen (green/gold cartoon) covalently attached to an [[ركيزة (كيمياء حيوية)]] [[مجموعة أسيل|أسيل]] intermediate (multicolor sticks, carbon = white, nitrogen = blue, oxygen = red) and an [[جلوكوزامين]]–[[مانوز]] [[سكر ثنائي]] ([[نموذج ملء الفراغ]], carbon = yellow and oxygen = red).<ref name="pmid18187150">{{PDB|2ZCK}}; {{Cite journal| author = Ménez R, Michel S, Muller BH, Bossus M, Ducancel F, Jolivet-Reynaud C, Stura EA | title = Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody | journal = J. Mol. Biol. | volume = 376 | issue = 4 | pages = 1021–33 | date =February 2008 | month = | pmid = 18187150 | doi = 10.1016/j.jmb.2007.11.052 }}</ref><br />
| PDB = {{PDB2|1PFA}}, {{PDB2|2PSA}}, {{PDB2|2ZCH}}, {{PDB2|2ZCK}}, {{PDB2|2ZCL}}, {{PDB2|3QUM}}<br />
| HGNCid = 6364<br />
| MGIid = 892021<br />
| Symbol = KLK3<br />
| AltSymbols =; APS; KLK2A1; PSA; hK3<br />
| IUPHAR = yes<br />
| ChEMBL = 2099<br />
| OMIM = 176820<br />
| ECnumber = 3.4.21.77<br />
| Homologene = 68141<br />
| GeneAtlas_image1 = PBB_GE_KLK3_204582_s_at_tn.png<br />
| GeneAtlas_image2 = PBB_GE_KLK3_204583_x_at_tn.png<br />
| GeneAtlas_image3 = <br />
| Protein_domain_image = <br />
| Function = {{GNF GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF GO|id=GO:0005515 |text = protein binding}} {{GNF GO|id=GO:0008236 |text = serine-type peptidase activity}}<br />
| Component = {{GNF GO|id=GO:0005576 |text = extracellular region}} {{GNF GO|id=GO:0005634 |text = nucleus}}<br />
| Process = {{GNF GO|id=GO:0006508 |text = proteolysis}} {{GNF GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF GO|id=GO:0044267 |text = cellular protein metabolic process}}<br />
| Hs_EntrezGene = 354<br />
| Hs_Ensembl = ENSG00000142515<br />
| Hs_RefseqmRNA = NM_001030047<br />
| Hs_RefseqProtein = NP_001025218<br />
| Hs_GenLoc_db = hg19<br />
| Hs_GenLoc_chr = 19<br />
| Hs_GenLoc_start = 51358171<br />
| Hs_GenLoc_end = 51364020<br />
| Hs_Uniprot = P07288<br />
| Mm_EntrezGene = 13646<br />
| Mm_Ensembl = ENSMUSG00000060177<br />
| Mm_RefseqmRNA = NM_010114<br />
| Mm_RefseqProtein = NP_034244<br />
| Mm_GenLoc_db = mm10<br />
| Mm_GenLoc_chr = 7<br />
| Mm_GenLoc_start = 44112673<br />
| Mm_GenLoc_end = 44116922<br />
| Mm_Uniprot = P15948<br />
| path = PBB/354<br />
}}<br />
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