https://3rabica.org/index.php?action=history&feed=atom&title=%D9%82%D8%A7%D9%84%D8%A8%3APBB%2F2147 2026-06-05T20:21:16Z تاريخ التعديل لهذه الصفحة في الويكي MediaWiki 1.43.7 https://3rabica.org/index.php?title=%D9%82%D8%A7%D9%84%D8%A8:PBB/2147&diff=190645&oldid=prev 2020-05-13T01:23:36Z

<p>بوت:إصلاح تحويلات القوالب</p> <p><b>صفحة جديدة</b></p><div>{{GNF_Protein_box<br /> | Name = Coagulation factor II (thrombin)<br /> | image = 2c93.png<br /> | image_source = The structure of human thrombin in complex with the inhibitor [[hirudin]].&lt;ref name=&quot;pmid16480269&quot;&gt;{{PDB|2C93}}; {{cite journal | author = Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL | title = Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors | journal = J. Med. Chem. | volume = 49 | issue = 4 | pages = 1346–55 | date = February 2006 | month = | pmid = 16480269 | doi = 10.1021/jm050850v | url = | issn = }}&lt;/ref&gt;<br /> | PDB = {{PDB2|1A2C}}, {{PDB2|1A3B}}, {{PDB2|1A3E}}, {{PDB2|1A46}}, {{PDB2|1A4W}}, {{PDB2|1A5G}}, {{PDB2|1A61}}, {{PDB2|1ABI}}, {{PDB2|1ABJ}}, {{PDB2|1AD8}}, {{PDB2|1AE8}}, {{PDB2|1AFE}}, {{PDB2|1AHT}}, {{PDB2|1AI8}}, {{PDB2|1AIX}}, {{PDB2|1AWF}}, {{PDB2|1AWH}}, {{PDB2|1AY6}}, {{PDB2|1B5G}}, {{PDB2|1B7X}}, {{PDB2|1BA8}}, {{PDB2|1BB0}}, {{PDB2|1BCU}}, {{PDB2|1BHX}}, {{PDB2|1BMM}}, {{PDB2|1BMN}}, {{PDB2|1BTH}}, {{PDB2|1C1U}}, {{PDB2|1C1V}}, {{PDB2|1C1W}}, {{PDB2|1C4U}}, {{PDB2|1C4V}}, {{PDB2|1C4Y}}, {{PDB2|1C5L}}, {{PDB2|1C5N}}, {{PDB2|1C5O}}, {{PDB2|1CA8}}, {{PDB2|1D3D}}, {{PDB2|1D3P}}, {{PDB2|1D3Q}}, {{PDB2|1D3T}}, {{PDB2|1D4P}}, {{PDB2|1D6W}}, {{PDB2|1D9I}}, {{PDB2|1DE7}}, {{PDB2|1DIT}}, {{PDB2|1DM4}}, {{PDB2|1DOJ}}, {{PDB2|1DWB}}, {{PDB2|1DWC}}, {{PDB2|1DWD}}, {{PDB2|1DWE}}, {{PDB2|1DX5}}, {{PDB2|1E0F}}, {{PDB2|1EB1}}, {{PDB2|1EOJ}}, {{PDB2|1EOL}}, {{PDB2|1FPC}}, {{PDB2|1FPH}}, {{PDB2|1G30}}, {{PDB2|1G32}}, {{PDB2|1G37}}, {{PDB2|1GHV}}, {{PDB2|1GHW}}, {{PDB2|1GHX}}, {{PDB2|1GHY}}, {{PDB2|1GJ4}}, {{PDB2|1GJ5}}, {{PDB2|1H8D}}, {{PDB2|1H8I}}, {{PDB2|1HAG}}, {{PDB2|1HAH}}, {{PDB2|1HAI}}, {{PDB2|1HAO}}, {{PDB2|1HAP}}, {{PDB2|1HBT}}, {{PDB2|1HDT}}, {{PDB2|1HGT}}, {{PDB2|1HLT}}, {{PDB2|1HUT}}, {{PDB2|1HXE}}, {{PDB2|1HXF}}, {{PDB2|1IHS}}, {{PDB2|1IHT}}, {{PDB2|1JMO}}, {{PDB2|1JOU}}, {{PDB2|1JWT}}, {{PDB2|1K21}}, {{PDB2|1K22}}, {{PDB2|1KTS}}, {{PDB2|1KTT}}, {{PDB2|1LHC}}, {{PDB2|1LHD}}, {{PDB2|1LHE}}, {{PDB2|1LHF}}, {{PDB2|1LHG}}, {{PDB2|1MH0}}, {{PDB2|1MU6}}, {{PDB2|1MU8}}, {{PDB2|1MUE}}, {{PDB2|1NM6}}, {{PDB2|1NO9}}, {{PDB2|1NRN}}, {{PDB2|1NRO}}, {{PDB2|1NRP}}, {{PDB2|1NRQ}}, {{PDB2|1NRR}}, {{PDB2|1NRS}}, {{PDB2|1NT1}}, {{PDB2|1NU7}}, {{PDB2|1NU9}}, {{PDB2|1NY2}}, {{PDB2|1NZQ}}, {{PDB2|1O0D}}, {{PDB2|1O2G}}, {{PDB2|1O5G}}, {{PDB2|1OOK}}, {{PDB2|1OYT}}, {{PDB2|1P8V}}, {{PDB2|1PPB}}, {{PDB2|1QBV}}, {{PDB2|1QHR}}, {{PDB2|1QJ1}}, {{PDB2|1QJ6}}, {{PDB2|1QJ7}}, {{PDB2|1QUR}}, {{PDB2|1RD3}}, {{PDB2|1RIW}}, {{PDB2|1SB1}}, {{PDB2|1SFQ}}, {{PDB2|1SG8}}, {{PDB2|1SGI}}, {{PDB2|1SHH}}, {{PDB2|1SL3}}, {{PDB2|1SR5}}, {{PDB2|1T4U}}, {{PDB2|1T4V}}, {{PDB2|1TA2}}, {{PDB2|1TA6}}, {{PDB2|1TB6}}, {{PDB2|1TBZ}}, {{PDB2|1THP}}, {{PDB2|1THR}}, {{PDB2|1THS}}, {{PDB2|1TMB}}, {{PDB2|1TMT}}, {{PDB2|1TMU}}, {{PDB2|1TOM}}, {{PDB2|1TQ0}}, {{PDB2|1TQ7}}, {{PDB2|1TWX}}, {{PDB2|1UMA}}, {{PDB2|1UVS}}, {{PDB2|1VR1}}, {{PDB2|1VZQ}}, {{PDB2|1W7G}}, {{PDB2|1WAY}}, {{PDB2|1WBG}}, {{PDB2|1XM1}}, {{PDB2|1XMN}}, {{PDB2|1YPE}}, {{PDB2|1YPG}}, {{PDB2|1YPJ}}, {{PDB2|1YPK}}, {{PDB2|1YPL}}, {{PDB2|1YPM}}, {{PDB2|1Z71}}, {{PDB2|1Z8I}}, {{PDB2|1Z8J}}, {{PDB2|1ZGI}}, {{PDB2|1ZGV}}, {{PDB2|1ZRB}}, {{PDB2|2A0Q}}, {{PDB2|2A2X}}, {{PDB2|2A45}}, {{PDB2|2AFQ}}, {{PDB2|2ANK}}, {{PDB2|2ANM}}, {{PDB2|2B5T}}, {{PDB2|2BDY}}, {{PDB2|2BVR}}, {{PDB2|2BVS}}, {{PDB2|2BVX}}, {{PDB2|2BXT}}, {{PDB2|2BXU}}, {{PDB2|2C8W}}, {{PDB2|2C8X}}, {{PDB2|2C8Y}}, {{PDB2|2C8Z}}, {{PDB2|2C90}}, {{PDB2|2C93}}, {{PDB2|2CF8}}, {{PDB2|2CF9}}, {{PDB2|2CN0}}, {{PDB2|2FEQ}}, {{PDB2|2FES}}, {{PDB2|2GDE}}, {{PDB2|2GP9}}, {{PDB2|2H9T}}, {{PDB2|2HGT}}, {{PDB2|2HNT}}, {{PDB2|2HPP}}, {{PDB2|2HPQ}}, {{PDB2|2HWL}}, {{PDB2|2JH0}}, {{PDB2|2JH5}}, {{PDB2|2JH6}}, {{PDB2|2OD3}}, {{PDB2|2PGB}}, {{PDB2|2PGQ}}, {{PDB2|2PKS}}, {{PDB2|2PW8}}, {{PDB2|2R2M}}, {{PDB2|2THF}}, {{PDB2|2UUF}}, {{PDB2|2UUJ}}, {{PDB2|2UUK}}, {{PDB2|2V3H}}, {{PDB2|2V3O}}, {{PDB2|2ZC9}}, {{PDB2|2ZDA}}, {{PDB2|2ZDV}}, {{PDB2|2ZF0}}, {{PDB2|2ZFF}}, {{PDB2|2ZFP}}, {{PDB2|2ZFQ}}, {{PDB2|2ZFR}}, {{PDB2|2ZG0}}, {{PDB2|2ZGB}}, {{PDB2|2ZGX}}, {{PDB2|2ZHE}}, {{PDB2|2ZHF}}, {{PDB2|2ZHQ}}, {{PDB2|2ZHW}}, {{PDB2|2ZI2}}, {{PDB2|2ZIQ}}, {{PDB2|2ZNK}}, {{PDB2|2ZO3}}, {{PDB2|3B23}}, {{PDB2|3B9F}}, {{PDB2|3BEF}}, {{PDB2|3BEI}}, {{PDB2|3BF6}}, {{PDB2|3BIU}}, {{PDB2|3BIV}}, {{PDB2|3BV9}}, {{PDB2|3C1K}}, {{PDB2|3C27}}, {{PDB2|3D49}}, {{PDB2|3DA9}}, {{PDB2|3DD2}}, {{PDB2|3DHK}}, {{PDB2|3DT0}}, {{PDB2|3DUX}}, {{PDB2|3E6P}}, {{PDB2|3EE0}}, {{PDB2|3EGK}}, {{PDB2|3EQ0}}, {{PDB2|3F68}}, {{PDB2|3GIC}}, {{PDB2|3GIS}}, {{PDB2|3HAT}}, {{PDB2|3HKJ}}, {{PDB2|3HTC}}, {{PDB2|3JZ1}}, {{PDB2|3JZ2}}, {{PDB2|3K65}}, {{PDB2|3LDX}}, {{PDB2|3LU9}}, {{PDB2|3NXP}}, {{PDB2|3P17}}, {{PDB2|3P6Z}}, {{PDB2|3P70}}, {{PDB2|3PMH}}, {{PDB2|3PO1}}, {{PDB2|3QDZ}}, {{PDB2|3QGN}}, {{PDB2|3QLP}}, {{PDB2|3QTO}}, {{PDB2|3QTV}}, {{PDB2|3QWC}}, {{PDB2|3QX5}}, {{PDB2|3R3G}}, {{PDB2|3RLW}}, {{PDB2|3RLY}}, {{PDB2|3RM0}}, {{PDB2|3RM2}}, {{PDB2|3RML}}, {{PDB2|3RMM}}, {{PDB2|3RMN}}, {{PDB2|3RMO}}, {{PDB2|3S7H}}, {{PDB2|3S7K}}, {{PDB2|3SHA}}, {{PDB2|3SHC}}, {{PDB2|3SI3}}, {{PDB2|3SI4}}, {{PDB2|3SQE}}, {{PDB2|3SQH}}, {{PDB2|3SV2}}, {{PDB2|3T5F}}, {{PDB2|3TU7}}, {{PDB2|3U69}}, {{PDB2|3U8O}}, {{PDB2|3U8R}}, {{PDB2|3U8T}}, {{PDB2|3U98}}, {{PDB2|3U9A}}, {{PDB2|3UTU}}, {{PDB2|3UWJ}}, {{PDB2|3VXE}}, {{PDB2|3VXF}}, {{PDB2|4AX9}}, {{PDB2|4AYV}}, {{PDB2|4AYY}}, {{PDB2|4AZ2}}, {{PDB2|4BAH}}, {{PDB2|4BAK}}, {{PDB2|4BAM}}, {{PDB2|4BAN}}, {{PDB2|4BAO}}, {{PDB2|4BAQ}}, {{PDB2|4BOH}}, {{PDB2|4CH2}}, {{PDB2|4CH8}}, {{PDB2|4DIH}}, {{PDB2|4DII}}, {{PDB2|4DT7}}, {{PDB2|4DY7}}, {{PDB2|4E05}}, {{PDB2|4E06}}, {{PDB2|4E7R}}, {{PDB2|4H6S}}, {{PDB2|4H6T}}, {{PDB2|4HFP}}, {{PDB2|4HTC}}, {{PDB2|4HZH}}, {{PDB2|4I7Y}}, {{PDB2|4LOY}}, {{PDB2|4LXB}}, {{PDB2|4LZ1}}, {{PDB2|4LZ4}}, {{PDB2|4MLF}}, {{PDB2|4N3L}}, {{PDB2|4NZE}}, {{PDB2|4NZQ}}, {{PDB2|4O03}}, {{PDB2|4RKJ}}, {{PDB2|4RKO}}, {{PDB2|4RN6}}, {{PDB2|4THN}}, {{PDB2|5GDS}}, {{PDB2|7KME}}, {{PDB2|8KME}}<br /> | HGNCid = 3535<br /> | MGIid = 88380<br /> | Symbol = F2<br /> | AltSymbols =; PT; RPRGL2; THPH1<br /> | IUPHAR = <br /> | ChEMBL = 204<br /> | OMIM = 176930<br /> | ECnumber = 3.4.21.5<br /> | Homologene = 426<br /> | GeneAtlas_image1 = PBB_GE_F2_205754_at_tn.png<br /> &lt;!-- The Following entry is a time stamp of the last bot update. It is typically hidden data --&gt;<br /> | GeneAtlas_image2 = <br /> | GeneAtlas_image3 = <br /> | Protein_domain_image = <br /> | Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0070053 |text = thrombospondin receptor activity}}<br /> | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005788 |text = endoplasmic reticulum lumen}} {{GNF_GO|id=GO:0005796 |text = Golgi lumen}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0031012 |text = extracellular matrix}} {{GNF_GO|id=GO:0070062 |text = extracellular exosome}} {{GNF_GO|id=GO:0072562 |text = blood microparticle}}<br /> | Process = {{GNF_GO|id=GO:0001934 |text = positive regulation of protein phosphorylation}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0007597 |text = blood coagulation, intrinsic pathway}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0010468 |text = regulation of gene expression}} {{GNF_GO|id=GO:0010544 |text = negative regulation of platelet activation}} {{GNF_GO|id=GO:0014068 |text = positive regulation of phosphatidylinositol 3-kinase signaling}} {{GNF_GO|id=GO:0014854 |text = response to inactivity}} {{GNF_GO|id=GO:0017187 |text = peptidyl-glutamic acid carboxylation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030193 |text = regulation of blood coagulation}} {{GNF_GO|id=GO:0030194 |text = positive regulation of blood coagulation}} {{GNF_GO|id=GO:0030307 |text = positive regulation of cell growth}} {{GNF_GO|id=GO:0032967 |text = positive regulation of collagen biosynthetic process}} {{GNF_GO|id=GO:0042730 |text = fibrinolysis}} {{GNF_GO|id=GO:0043687 |text = post-translational protein modification}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}} {{GNF_GO|id=GO:0045861 |text = negative regulation of proteolysis}} {{GNF_GO|id=GO:0048712 |text = negative regulation of astrocyte differentiation}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}} {{GNF_GO|id=GO:0051281 |text = positive regulation of release of sequestered calcium ion into cytosol}} {{GNF_GO|id=GO:0051480 |text = cytosolic calcium ion homeostasis}} {{GNF_GO|id=GO:0051918 |text = negative regulation of fibrinolysis}} {{GNF_GO|id=GO:0071260 |text = cellular response to mechanical stimulus}} {{GNF_GO|id=GO:1900738 |text = positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway}} {{GNF_GO|id=GO:2000379 |text = positive regulation of reactive oxygen species metabolic process}}<br /> | Hs_EntrezGene = 2147<br /> | Hs_Ensembl = ENSG00000180210<br /> | Hs_RefseqmRNA = NM_000506<br /> | Hs_RefseqProtein = NP_000497<br /> | Hs_GenLoc_db = hg38<br /> | Hs_GenLoc_chr = 11<br /> | Hs_GenLoc_start = 46719180<br /> | Hs_GenLoc_end = 46739506<br /> | Hs_Uniprot = P00734<br /> | Mm_EntrezGene = 14061<br /> | Mm_Ensembl = ENSMUSG00000027249<br /> | Mm_RefseqmRNA = NM_010168<br /> | Mm_RefseqProtein = NP_034298<br /> | Mm_GenLoc_db = mm10<br /> | Mm_GenLoc_chr = 2<br /> | Mm_GenLoc_start = 91625320<br /> | Mm_GenLoc_end = 91636414<br /> | Mm_Uniprot = P19221<br /> | path = PBB/2147<br /> }}<br /> &lt;noinclude&gt;{{قائمة مراجع قالب}}&lt;/noinclude&gt;</div>

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