https://3rabica.org/index.php?action=history&feed=atom&title=%D9%82%D8%A7%D9%84%D8%A8%3APBB%2F10203 2026-06-06T08:50:15Z تاريخ التعديل لهذه الصفحة في الويكي MediaWiki 1.43.7 https://3rabica.org/index.php?title=%D9%82%D8%A7%D9%84%D8%A8:PBB/10203&diff=164413&oldid=prev 2022-02-17T10:46:39Z

<p>بوت: إصلاح التحويلات</p> <p><b>صفحة جديدة</b></p><div>{{GNF_Protein_box<br /> | Name = Calcitonin receptor-like<br /> | image = 3N7S.pdb.png<br /> | image_source = [[دراسة البلورات بالأشعة السينية#Biological_macromolecular_crystallography|Crystallographic structure]] of the ectodomain complex of the CGRP type 1 receptor and [[بروتين معدل لنشاط المستقبل 1|RAMP1]].&lt;ref name=&quot;pmid20826335&quot;&gt;{{PDB|3N7S}}; {{cite journal | author = ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM | title = Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism | journal = Structure | volume = 18 | issue = 9 | pages = 1083–93 | year = 2010 | pmid = 20826335 | doi = 10.1016/j.str.2010.05.014 | url = | issn = }}&lt;/ref&gt;<br /> | PDB = {{PDB2|3AQF}}, {{PDB2|3N7P}}, {{PDB2|3N7R}}, {{PDB2|3N7S}}, {{PDB2|4RWF}}, {{PDB2|4RWG}}<br /> | HGNCid = 16709<br /> | MGIid = 1926944<br /> | Symbol = CALCRL<br /> | AltSymbols =; CGRPR; CRLR<br /> | IUPHAR = yes<br /> | ChEMBL = 3798<br /> | OMIM = 114190<br /> | ECnumber = <br /> | Homologene = 21179<br /> | GeneAtlas_image1 = PBB_GE_CALCRL_206331_at_tn.png<br /> | GeneAtlas_image2 = PBB_GE_CALCRL_210815_s_at_tn.png<br /> | GeneAtlas_image3 = <br /> | Protein_domain_image = <br /> | Function = {{GNF_GO|id=GO:0001605 |text = adrenomedullin receptor activity}} {{GNF_GO|id=GO:0001635 |text = calcitonin gene-related peptide receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004948 |text = calcitonin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}<br /> | Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral component of plasma membrane}}<br /> | Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007189 |text = adenylate cyclase-activating G-protein coupled receptor signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0030819 |text = positive regulation of cAMP biosynthetic process}} {{GNF_GO|id=GO:0031623 |text = receptor internalization}} {{GNF_GO|id=GO:0045986 |text = negative regulation of smooth muscle contraction}} {{GNF_GO|id=GO:0048661 |text = positive regulation of smooth muscle cell proliferation}} {{GNF_GO|id=GO:0050728 |text = negative regulation of inflammatory response}} {{GNF_GO|id=GO:0071329 |text = cellular response to sucrose stimulus}}<br /> | Hs_EntrezGene = 10203<br /> | Hs_Ensembl = ENSG00000064989<br /> | Hs_RefseqmRNA = NM_001271751<br /> | Hs_RefseqProtein = NP_001258680<br /> | Hs_GenLoc_db = hg38<br /> | Hs_GenLoc_chr = 2<br /> | Hs_GenLoc_start = 187343129<br /> | Hs_GenLoc_end = 187448460<br /> | Hs_Uniprot = Q16602<br /> | Mm_EntrezGene = 54598<br /> | Mm_Ensembl = ENSMUSG00000059588<br /> | Mm_RefseqmRNA = NM_018782<br /> | Mm_RefseqProtein = NP_061252<br /> | Mm_GenLoc_db = mm10<br /> | Mm_GenLoc_chr = 2<br /> | Mm_GenLoc_start = 84330626<br /> | Mm_GenLoc_end = 84425411<br /> | Mm_Uniprot = Q9R1W5<br /> | path = PBB/10203<br /> }}<br /> &lt;noinclude&gt;{{قائمة مراجع قالب}}&lt;/noinclude&gt;</div>

عبد العزيز